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RUNX1T1 (8q21.3) Orange FISH Probe is intended to hybridize to the 8q21.3 region on chromosome 8. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history by a qualified pathologist.
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The RUNX1T1 gene encodes a protein involved in regulating transcription and is known as the translocation partner 1 of RUNX1. The genomic rearrangements in the RUNX1-RUNX1T1 translocations are well documented and are clinically associated with Acute Myeloid Leukemia.1,2
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1. Håkon Reikvam, Kimberley Joanne Hatfield, Astrid Olsnes Kittang, Randi Hovland, and Øystein Bruserud, “Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 104631, 23 pages, 2011. doi:10.1155/2011/104631
2. Lucena-Araujo, A.R., de Figueiredo-Pontes, L.L., de Oliveira, F.M. et al. Med Oncol (2012) 29: 1114. doi:10.1007/s12032-011-9890-3
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.