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RUNX1 (21q22) Green FISH Probe is intended to hybridize to the 21q22.12 probe region on chromosome 21. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history by a qualified pathologist.
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The RUNX1 gene encodes a protein called the runt-related transcription factor 1. The transcription factor binds to the DNA encoding proteins involved in the regulation of hematopoiesis. 1
Mutations in RUNX1 DNA, such as fusions with ETV6, are well documented in various leukemias such as acute lymphoblastic leukemia (ALL).2
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1. Goyama, Susumu et al. “Transcription Factor RUNX1 Promotes Survival of Acute Myeloid Leukemia Cells.” The Journal of Clinical Investigation 123.9 (2013): 3876–3888. PMC. Web. 25 Aug. 2017.
2. Bhojwani, Deepa et al. “ETV6-RUNX1-Positive Childhood Acute Lymphoblastic Leukemia: Improved Outcome with Contemporary Therapy.” Leukemia 26.2 (2012): 265–270. PMC. Web. 25 Aug. 2017.
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.