RUNX1 (21q22) Green FISH Probe is intended to hybridize to the 21q22.12 probe region on chromosome 21. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history by a qualified pathologist.
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The RUNX1 gene encodes a protein called the runt-related transcription factor 1. The transcription factor binds to the DNA encoding proteins involved in the regulation of hematopoiesis. 1
Mutations in RUNX1 DNA, such as fusions with ETV6, are well documented in various leukemias such as acute lymphoblastic leukemia (ALL).2