This DNA negative control probe consists of a random set of oligonucleotide sequences with a GC content of 40-70%. It should be used to assess non-specific staining when performing in situ hybridization. No positive staining should result with the use of this probe. The in situ hybridization technique offers an important advantage over immunohistochemistry, as it virtually lacks background, and allows a clean and sharp viewing of the histological preparation.
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