MUC-1

SKU: 319 Categories: M, Primary Antibodies Tags: 319, CM 319, CM319, PM 319, PM319

MUC-1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC-1 is secreted from tumor cells. MUC-1 antibody stains cell membranes, but also the cytoplasm of most epithelial cell types. It is expressed abundantly in lactating mammary glands and over-expressed in >90% breast carcinomas and late-stage epithelial ovarian cancers. Aberrant cytoplasmic and membranous localization of MUC-1 expression has been associated with poor patient outcome. Adenocarcinomas are generally positive while squamous carcinomas and non-epithelial malignancies are negative.

Intended Use	IVD
Species Reactivity	Human
Source	Mouse Monoclonal
Isotype	IgG1
Antigen	MUC-1
Localization	Cytoplasmic/cell membrane
Positive Control	Lung

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