MUC-1

Product Description

MUC-1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC-1 is secreted from tumor cells. MUC-1 antibody stains cell membranes, but also the cytoplasm of most epithelial cell types. It is expressed abundantly in lactating mammary glands and over-expressed in >90% breast carcinomas and late-stage epithelial ovarian cancers. Aberrant cytoplasmic and membranous localization of MUC-1 expression has been associated with poor patient outcome. Adenocarcinomas are generally positive while squamous carcinomas and non-epithelial malignancies are negative.

Specifications

1. Rakha EA et al. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. 2005 Oct; 18(10): 1295-304.
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3. Rakha EA, Boyce RW, Abd El-Rehim D, Kurien T, Green AR, Paish EC, Robertson JF, Ellis IO. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. 2005 Oct;18(10):1295-304.
4. Nassar H, Pansare V, Zhang H, Che M, Sakr W, Ali-Fehmi R, Grignon D, Sarkar F,Cheng J, Adsay V. Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. Mod Pathol. 2004 Sep;17(9):1045-50.
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7. Ohno T, Aihara R, Kamiyama Y, Mochiki E, Asao T, Kuwano H. Prognostic significance of combined expression of MUC1 and adhesion molecules in advanced gastric cancer. Eur J Cancer. 2006 Jan;42(2):256-63. Epub 2005 Dec 13.
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