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Helicobacter pylori (H. pylori) infection represents the major cause of peptic ulcer disease and is a likely contributing factor in the development of gastric neoplastic diseases such as gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma (1). H. pylori are spiral-curved, gram-negative bacteria. The majority of H. pylori microorganisms reside in the unstirred layer of the gastric mucus, but some bind to the luminal aspect of gastric foveolar cells, and attach at or near intercellular junctions, or even locate within cells (2-3). However, generally they do not invade the underlying lamina propria (3). Immunohistochemical (IHC) detection of H. pylori can specifically distinguish the microorganisms from other types of bacterial infections. Complete staining of the H. pylori microrganism has been shown with the rabbit monoclonal. An IHC technique, with heat-induced-antigen retrieval for detection of H. pylori in gastric biopsies, is highly reliable, highly sensitive, specific, and can be used on fully automated IHC platforms.
6.0 ml, 60 Tests
Human; others not tested
Spiral shaped bacterium
Gastric tissue infected with H. pylori
1. Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev. 1997;10:720-41.
2. Boren T, et al. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science. 1993; 262:1892-5.
3. Hazell SL, et al. Campylobacter pyloridis and gastritis: association with inter cellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithlium. J Infect Dis. 1986;153:658-63.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.