ETV6 (12p13) Orange

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SKU: 7275 Categories: , , ,

ETV6 (12p13) Orange FISH Probe is intended to hybridize to the 12p13.2 probe region on chromosome 12. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history by a qualified pathologist.

FOR DISTRIBUTION OUTSIDE THE UNITED STATES ONLY

The ETV6 gene enocodes a N-terminal pointed domain (PNT) resulting in protein-protein interactions as well as a C-terminal domain facilitating DNA binding. ETV6 translocations can result in the ETV6/RUNX1 fusion, a well documented event in the pathogenesis of acute lymphoblastic leukemia (ALL)1. The detection of these mutations can provide clinical insight for ALL treatment.2

Intended Use

IVD

Volume

100 µl

Color

Orange

By Letter

E

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Legal Notice

IVD is NOT for Sale in the United States but may be available in certain countries outside of the United States, please contact your local distributor for more information.

1. Mindaugas Stoskus, Goda Vaitkeviciene, Audrone Eidukaite, Laimonas Griskevicius, ETV6/RUNX1 transcript is a target of RNAbinding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia, Blood Cells, Molecules, and Diseases, Volume 57, 2016, Pages 30-34, ISSN 1079-9796
2. Bhojwani, Deepa et al. “ETV6-RUNX1-Positive Childhood Acute Lymphoblastic Leukemia: Improved Outcome with Contemporary Therapy.” Leukemia 26.2 (2012): 265–270. PMC. Web. 25 Aug. 2017.
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.