CD15 is present in greater than 90% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is expressed in Reed-Sternberg cells of Hodgkin’s disease (nodular sclerosis, mixed cellularity and lymphocyte-depleted subtypes), and on certain types of epithelial cells. It is generally agreed that the Reed-Sternberg cell variants in lymphocytepredominant Hodgkin’s disease are not reactive with CD15.
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