Amplication of the 1q21 locus has been demonstrated in hepatocellular carcinoma and represents one of the most frequently detected genomic alterations in that disease1. Further, the 1q21.3 region has also been reported to harbor a gene that has been shown to demonstrate a high level of expression in prostate cancer2.
Principle of Procedure
The 1q21.3 Orange Probe is designed to provide coverage of the 1q21.3 (~548 kb) region of chromsome 1. The Copy Control 1p12 Green Probe is designed to provide coverage of the 1p21.2 (~475 kb) region of chromosome 1. A normal cell would show two orange and two green signals.