CD138 / syndecan-1 protein backbone is a single chain molecule of 30.5 kDa. Five putative GAG attachment sites exist in the extracellular domain. GAG fine structure appears to reflect the cellular source of the syndecan. Expression of CD138 in human hematopoietic cells is restricted to plasma cells in normal bone marrow. Early B-cell precursors in […]
CD117/c-kit is a member of Tyrosine Kinase Receptor (TKR) family and highly homologous to receptor PDGF and CSF-1. This antibody recognizes the extracellular domain and is expressed by a variety of normal and abnormal cell types.15
Human CD10, also known as common acute lymphoblastic leukemia (CALLA), has been shown to react with TdT+ lymphoblastic leukemia, follicular germinal cell lymphoma, Burkitt’s lymphoma, and chronic myelocytic leukemia.15
The oncogene-encoded protein c-Myc is postulated to play a role in activating the transcription of growth related genes. Amplification of the c-Myc gene has been found in several types of human tumors. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in neoplastic disease. c-Myc oncogene activity may also be necessary for the […]
This antibody recognizes a protein of 185 kDa, identified as the second member (cerbB-2/HER-2) of the c-erbB family. This rabbit monoclonal antibody is directed against the cytoplasmic domain of the human c-erbB-2 protein. The c-erbB-2 is closely related in structure to the epidermal growth factor receptor.
BOB-1 antibody is a B-lymphocyte-specific transcriptional co-activator for Oct-1 and Oct-2 transcription factors. BOB-1 and Oct-2 are useful for the B-lineage determination of CD20-plasmablastic or primary effusion subtypes of diffuse large B-cell lymphoma (DLBCL). Other studies have shown BOB-1, CD79a and Cyclin E are useful markers for discriminating classical Hodgkin’s lymphoma from primary mediastinal large […]
Biotinylated Bromodeoxyuridine Antibody recognizes bromodeoxyuridine (BrdU), an analog to thymidine and can be incorporated into replicating DNA during the S-phase of the cell cycle. The BrdU antibody can be used for DNA labeling index, evaluation of DNA synthesis and cell proliferation studies. This antibody is biotinylated and thus eliminates the need for a biotinylated secondary […]
Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers of squamous epithelial, hepatocytes and parietal cells.15-17 Want to Learn More About Ber-EP4 Antibody? Download Our Complimentary White Paper!
The Bcl-6 gene, originally cloned from a tumor with 3q27 translocation, is commonly expressed in large cell lymphomas. In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed to be important in germinal center formation. Bcl-6 protein is expressed mainly by follicle center cells and in a few interfollicular T-lymphocytes. Bcl-6 has […]
The 100/D5 antibody is highly specific to Bcl-2 antibody (alpha) and shows no cross-reactivity with Bcl-x or Bax protein. Bcl-2 (b-cell lymphoma #2) is a proto-oncogene located at 18q21.3. Expression of Bcl-2 alpha oncoprotein has been shown to inhibit apoptosis. In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 protein, whereas the […]
