CD23 is a 45 kDa glycoprotein that acts as a receptor for IgE. It is expressed by interleukin-4 activated B-lymphocytes, by activated macrophages, and by a proportion of follicular dentritic cells. CD23 has been shown to be useful for the differentiation of small lymphocytic lymphomas and mantle cell lymphoma.15
CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. Studies have shown that CD22 antibody is expressed in both the cytoplasm and cell membrane of B-lymphocytes, and strongly expressed in hairy cell leukemia. Unlike other B-cell markers, CD22 membrane expression is limited to the late differentiation stages comprised […]
CD21, also known as complement receptor 2 and C3d receptor, is a 140-kD membrane protein on mature B-lymphocytes.15 CD21 has been shown to label follicular dendritic cells (FDC), as a means of illustrating the phenomenon of follicular colonization in marginal zone lymphoma. CD21 has also been used in proving cell lineage in some rare tumors […]
This antibody is optimized to work with Biocare Medical’s PromARK™ detection products for animal tissues. CD20 antibody (P) is a 33 kDa leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. CD20 is expressed primarily on B-cells but has also been detected on both normal and neoplastic T-cells. This gene encodes […]
CD20 [L26] reacts with a protein of a 30-33 kDa polypeptide present in Bcells. L26 reacts with the majority of B-cells present in peripheral blood and lymphoid tissues.15-17 In normal lymphoid tissue, L26 marks B-cells in germinal centers, particularly immunoblasts. This antibody has been shown to be a reliable marker as a pan B-cell marker. […]
CD1a antibody is a protein of 43 to 49kD expressed on dendritic cells and cortical thymocytes. CD1a staining has been shown to be useful in aiding the differentiation of Langerhans cells from inter-digitating cells. A study observed that a decline in Langerhans cells is linked to progressing grades of oral epithelial dysplasia and oral squamous […]
The Biocare CD19 antibody detects CD19, a 95 kDa cell surface glycoprotein expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 functions as a coreceptor with CD21 and plays a critical role in B-cell signal transduction, regulating development, activation, and differentiation.15,16 CD19 is expressed in pre-B cells and B cells and is […]
CD163 is useful in identifying cells of monocyte/macrophage lineage in normal and neoplastic conditions.15,16 This antibody reacts with human scavenger receptor cysteine-rich protein CD163 (p155, M130) found on mononuclear phagocytes including human monocytes and macrophages.15
CD15 is present in greater than 90% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is expressed in Reed-Sternberg cells of Hodgkin’s disease (nodular sclerosis, mixed cellularity and lymphocyte-depleted subtypes), and on certain types of epithelial cells. It is generally agreed that the Reed-Sternberg cell variants in lymphocytepredominant Hodgkin’s […]
CD15 MMA antibody is reported to be present on greater than 90% of granulocytes including neutrophils and eosinophils and to a lesser degree, on monocytes. CD15 has been reported to be expressed in Reed-Sternberg cells of Hodgkin’s disease (of the nodular sclerosis, mixed cellularity and lymphocyte-depleted subtypes) and certain types of epithelial cells. It is […]
