![Diffuse Large B-Cell Lymphoma (DLBCL) stained with CD20 [BC44] antibody.](https://biocare.net/wp-content/uploads/3316.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B cell lymphoma cells […]
![(L) Mesothelioma stained with MTAP [A8N9F] (R) Mesothelioma stained with MTAP [A8N9F] exhibiting expression loss.](https://biocare.net/wp-content/uploads/3302.jpg)
Methylthioadenosine phosphorylase (MTAP) is a protein product of the tumor suppressor gene located in the chromosome 9p21 region, close to the p16 gene (CDKN2), which plays an important role in the metabolism of purines and polyamines.15 The loss of MTAP immunoreactivity is frequently seen in malignant mesothelioma. MTAP is a helpful marker identification of malignant […]
![Pancreatic neuroendocrine tumor stained with PGP9.5 [UCHL1/4556R] antibody.](https://biocare.net/wp-content/uploads/3305.jpg)
Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts.15 The protein is highly conserved and localized in neurons and neuroendocrine cells, forming an estimated 5-10% of cytoplasmic protein.16 The detection of fine nerves in peripheral tissues using PGP 9.5 antibodies is […]
The NeoPATH Pro Universal AP Plus Polymer Kit is designed using a one-step or two-step method for detecting mouse and/or rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the one-step method a secondary antibody directly linked to the micro-polymer is applied while in the two-step […]
The NeoPATH Pro Antigen Retrieval 1 (AR1) is designed as a Tris-EDTA-based buffer used in heat-induced antigen retrieval (HIER) of formalin-fixed, paraffin-embedded (FFPE) tissues. HIER is the process of heating the slide-mounted specimen material in an antigen retrieval solution, followed by a cooling-off period. Retrieval solutions with paraffin emulsifiers (surfactants) followed by a rinsing reagent […]
The NeoPATH Pro Rabbit Amp AP Plus Kit is designed using a one-step method for detecting rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the one-step method a secondary antibody directly linked to the micropolymer is applied and an additional enzyme-linked polymer labeled reagent is […]
The Dewax Solutions 1 (DS1) is a water-based solution for the removal of paraffin wax from FFPE tissue specimens, as part of an IHC staining procedure on the ONCORE Pro Automated Slide Stainer. Removal of paraffin wax must be performed prior to antigen retrieval and the application of reagents for immunostaining. The solution is provided […]
The Dewax Solutions 1 (DS1) is a water-based solution for the removal of paraffin wax from FFPE tissue specimens, as part of an IHC staining procedure on the ONCORE Pro Automated Slide Stainer. Removal of paraffin wax must be performed prior to antigen retrieval and the application of reagents for immunostaining. The solution is provided […]
EcoMount is a fast-drying, optically clear, permanent mounting medium. This polymer-based mounting medium does not contain hazardous reagents such as xylene, toluene or benzene as its base solvent. EcoMount is designed especially for the permanent preservation of horseradish peroxidase, alkaline phosphatase and Qdot (quantum dot nanocrystals) immunofluorescent techniques. EcoMount permits long-term storage of slides with […]
Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes and has been implicated in embryogenesis, hematopoiesis, and neuronal and terminal epithelial differentiation.15 TLE1 is involved in the Wnt/β-catenin signaling pathway, which is important in synovial sarcomas, and in […]
