The Biocare CD33 antibody detects CD33 (Siglec-3), a 67 kDa glycosylated transmembrane receptor expressed on myeloid-specific cells.15, 16 Historically, CD33 was primarily used for flow cytometry; more recently, a paraffin embedded tissue–compatible CD33 antibody has been developed. CD33 is useful for phenotyping acute myelogenous leukemias, with immunohistochemical (IHC) analysis providing results equivalent to flow cytometry.15, […]
The excision repair cross-complementation group 1 (ERCC1) gene encodes a protein required for nucleotide excision repair and inter-strand crosslink repair of DNA (1). While DNA-damaging chemotherapeutic drugs like cisplatin are commonly used for non-small cell lung carcinoma and other late-stage tumors, these drugs have a high degree of resistance and severe side effects (1,3). Platinum […]
The Lambda Light Chain [N10/2] antibody is a mouse monoclonal antibody developed for the detection of lambda light chains of human immunoglobulins. Immunoglobulin light chains exist in two classes: kappa and lambda. In healthy individuals, the kappa to lambda ratio is approximately 2:1.19-20 Detection of light chain restriction can aid in the diagnosis of lymphoid […]
This antibody recognizes kappa light chains of human immunoglobulins, which may be useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas (1-5). The most common feature of these malignancies is the restricted expression of a single light chain class. The normal human kappa/lambda ratio is approximately 2:1. The presence of clear cut light […]
The Biocare CD103 [EP206] antibody detects the integrin subunit CD103, a cell surface antigen characteristically expressed in hairy cell leukemia (HCL), a Bcell lymphoproliferative disorder.15,17 CD103 [EP206] has demonstrated reactivity in formalin-fixed paraffinembedded (FFPE) tissue, eliminating the need for flow cytometry or frozen section IHC and making it a valuable component of an IHC panel […]
The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 is expressed in multipotent neuronal stem cells, and may aid to identify cells that are capable of self-renewal and multipotent differentiation (1-3). SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, […]
Achaete-scute complex homolog-1 (ASCL1), known as mASH1 in rodents and hASH1 in humans, is a basic helix-loop-helix transcription factor that is critical for neuroendocrine cell differentiation (1,2). Neuroendocrine carcinomas can arise in different sites such as lung, the gastrointestinal tract, prostate and skin (2). High grade, poorly differentiated neuroendocrine carcinomas are classified as neuroendocrine carcinomas […]
The Biocare IgG4 [HP6025] antibody detects human IgG4, a subclass of immunoglobulin G, and specifically recognizes the Fc region. Mouse monoclonal IgG4 [HP6025] is highly specific and may be useful in the diagnosis of IgG4-related systemic disease (IgG4-RSD), also known as IgG4-related sclerosing disease, which can affect multiple organs and is characterized by lymphoplasmacytic infiltration, […]
Kappa (M), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Kappa Light Chain [L1C1], catalog numbers ACI3149, API3149 as a substitute. Kappa M Antibody antibody recognizes kappa light chains of human immunoglobulins, which may be useful in the […]
Lambda (P), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Lambda Light Chain [N10/2], catalog numbers ACI3063, API3063 as a substitute. This antibody recognizes lambda light chains of human immunoglobulins, which may be useful in the identification of […]
