In human prostate cancer, the ERG oncogene is frequently overexpressed due to chromosomal translocations involving ERG and regulatory sequences of the TMPRSS2 or other androgen responsive genes. Recently, a mouse monoclonal anti-ERG antibody was developed with an unprecedented 99.9% specificity for detecting prostatic adenocarcinoma. The report shows strong correlation between the expression of the ERG […]
In human prostate cancer, the ERG oncogene is frequently overexpressed due to chromosomal translocations involving ERG and regulatory sequences of the TMPRSS2 or other androgen responsive genes. In particular, the TMPRSS2:ERG fusion gene has been found to be the most frequent gene rearrangement in prostate cancers, occurring in 45-65% of North American patients. A mouse […]
D2-40 reacts with an O-linked sialoglycoprotein (MW 40 kDa) found in lymphatic endothelium, fetal testis and on the surface of testicular germ-cell tumors. D2-40 is a new selective marker of lymphatic endothelium in normal tissues and vascular lesions. In recent studies, clone D2-40 has shown a staining reaction in lymphatic channel endothelium, but not in […]
![Prostate stained with CK HMW [34βE12]](https://biocare.net/wp-content/uploads/3056.jpg)
CK HMW [34BE12], 3X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin HMW [34βE12], catalog numbers CM127, PM127, IPI127, OAI127 as a substitute. 34βE12 recognizes cytokeratins (CK) 1, 5, 10 and 14 (1). In normal prostate, 34βE12 typically […]
α-Methylacyl coenzyme A racemase (AMACR Antibody), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry, AMACR Antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found […]
α-Methylacyl coenzyme A racemase (AMACR antibody), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry (IHC), AMACR antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been […]
