The excision repair cross-complementation group 1 (ERCC1) gene encodes a protein required for nucleotide excision repair and inter-strand crosslink repair of DNA (1). While DNA-damaging chemotherapeutic drugs like cisplatin are commonly used for non-small cell lung carcinoma and other late-stage tumors, these drugs have a high degree of resistance and severe side effects (1,3). Platinum […]
PIK3CA mutations have been discovered in many cancers including, colon, breast, endometrial, brain, skin, gastric, lung and thyroid1,2. Extensive studies have led researchers to believe that PIK3CA is one of the most commonly mutated oncogenes in human cancers3. These amplification events can be readily identified using appropriate FISH probes.
The p63 + CK5 Multiplex IHC stain has been especially designed for squamous cell carcinomas, particularly those derived in lung cancer. p63, a homolog of the tumor suppressor p53, has been identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate.15 CK5 is a 58 […]
The Muscle Specific Actin antibody [HHF35] recognizes muscle specific alpha and gamma actin isomers. It does not react with non-muscle actin. Studies have shown that it recognizes the alpha actin from cardiac, skeletal and smooth muscle sources. It does not react with beta or non-smooth muscle gamma actin isomers. The antibody labels leiomyoma, leiomyosarcoma, angiomyolipoma […]
The Ki-67 nuclear antigen is associated with cell proliferation. It is found throughout the cell cycle in the G1, S, G2, and M phases; but not the (GO) phase. It is used to grade proliferation rates of tumors. The high affinity and/or binding capacity of rabbit antibodies provide superior staining results and less chance for […]
This antibody reacts with Herpes Simplex Virus (HSV) 2. HSV 2 antibody identifies major viral envelope glycoproteins and core proteins that can be found in the cytoplasm and/or nucleus. HSV can infect both the peripheral and central nervous system. Studies have shown that HSV Type 2 infects the genitals and anus. Studies have shown this […]
GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kDa nuclear protein regulates the development and is expressed in specific cell types within a variety of tissues.1,2 GATA-3 is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and […]
CD57 antibody [NK-1] marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Studies have shown that CD57 expression is present in normal and neoplastic pituitaries. It has been reported that CD57 reactivity may be used as an additional immunophenotypic criterion […]
