Research has shown that deletions of PTEN occur at a very high frequency in prostate cancer (1). Other studies have demonstrated an association between decreased PTEN protein expression and a higher Gleason grade and advanced tumor stage (2). In a study by Yoshimoto, it was demonstrated that the presence of PTEN genomic losses are frequent […]
Antigen Retrieval 3 (AR3) is capable of partially breaking the covalent bonds of formalin-fixed tissue, as part of an ISH staining procedure on the ONCORE Pro Automated Slide Stainer. Pretreatment of FFPE tissues with Antigen Retrieval 3 (AR3) can increase staining intensity. Probe Enhancer (RNA) is an ancillary hybridization reagent that promotes spreading and reduces […]
The ONCORE Pro-Tect Detection Kit is designed using a two-step or threestep method for detecting mouse and/or rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the two-step method (rabbit), the universal linker is applied, then an additional enzyme-linked polymer labeled reagent is sequentially applied. In […]
![Uterus stained with Mast Cell Tryptase [AA1] antibody](https://biocare.net/wp-content/uploads/3277.jpg)
Mast Cell Tryptase, also known as Tryptase, is a serine protease predominantly produced and stored in mast cells. It has been studied for its involvement in biological processes such as tissue remodeling and angiogenesis.15,16 According to published literature, mast cells expressing Tryptase have been observed in a variety of human tissues, including those from hematologic […]
![Liver cancer stained with CD47 [EPR21794] antibody](https://biocare.net/wp-content/uploads/3284.jpg)
CD47 has been shown to have a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.15 In the brain, it appears to play an important role in memory formation and synaptic plasticity in the hippocampus.16 CD47 is a receptor for SIRPA, binding to […]
CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), can hydrolyze extracellular ATP and ADP. It is one of the key enzymes in the adenosine pathway and targeted adenosine may play a role in antitumor strategies.15 CD39 pathway inhibits natural killer (NK) cells and promotes the metastasis of tumors.15 Overexpression of CD39 has been observed […]
![Colon cancer stained with SATB2 [CL0323] antibody](https://biocare.net/wp-content/uploads/3259-SATB2.jpg)
SATB2 (special AT-rich sequence binding 2) is a human DNA-binding protein involved in transcriptional regulation and chromatin remodeling.15,16 SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract including appendix, colon and rectum. SATB2 protein expression was also found in non–germinal center lymphoid cells, and the ductal epithelium […]
TRBC1 is a rabbit polyclonal antibody that is intended for laboratory use after the initial diagnosis of tumor has been made by conventional histopathology using nonimmunologic histochemical stains, in the qualitative identification of TRBC1 protein by immunohistochemistry (IHC) in formalin-fixed paraffinembedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be […]
NPM1 is a rabbit polyclonal antibody that is intended for laboratory use after the initial diagnosis of tumor has been made by conventional histopathology using nonimmunologic histochemical stains, in the qualitative identification of NPM1 protein by immunohistochemistry (IHC) in formalin-fixed paraffinembedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be […]
![Tonsil stained with CD19 (RM) [RM332] antibody](https://biocare.net/wp-content/uploads/3270-1.jpg)
The Biocare CD19 antibody detects CD19, a transmembrane glycoprotein of the immunoglobulin superfamily encoded by the CD19 gene and regulated by the B-cell-specific activator protein (BSAP).15 CD19 is expressed across nearly all developmental and activation-dependent stages of B-cell differentiation and serves as a key regulator of antigendependent B-cell activation.15 It is expressed in various B-cell […]
