Biocare’s Multiplex IHC Tests Biocare introduces the Lung Adeno-2™ and Lung Squamous-2™ Multiplex IHC tests which aid in the critical differentiation of NSCLC squamous cell carcinoma vs. adenocarcinoma(1) with 100% specificity for squamous cell carcinoma and 79% sensitivity for adenocarcinoma. This differentiation is a critical component in therapeutic decisions such as the use of VEGF […]
16
Oct
Oct
Thyroid transcription factor-1 (TTF-1) is a member of the NKX2 family of homeodomain transcription factors. Studies have shown that TTF-1 is expressed in epithelial cells of the thyroid gland and lung. TTF-1 has been shown to be a sensitive (62-80%) and specific marker (89-95%) in the majority of primary lung adenocarcinomas (ADC) (1-7). When combined […]
14
Apr
Apr
Desmoglein 3 (M), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Desmoglein 3, catalog numbers CM419, PM419 as a substitute. Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein […]
11
Apr
Apr
CK5 (RM), 2X (Lung) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5 (CK5), catalog numbers CME430, PME430 as a substitute. CK5 is a type II intermediate filament protein that is expressed in active basal layers of most […]
05
Feb
Feb
Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily (1,2). Desmogleins exhibit membranous expression and connect with cytokeratins through desmoplakins and plakoglobin. DSG3 is particularly important in the cellular adhesion […]
24
Sep
Sep
The p63 + CK5 Multiplex IHC stain has been especially designed for squamous cell carcinomas, particularly those derived in lung cancer. p63, a homolog of the tumor suppressor p53, has been identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate.15 CK5 is a 58 […]
24
Sep
Sep
p63, a homolog of the tumor suppressor p53, has been identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate.15 p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate.16 As […]
16
Sep
Sep
The Cytokeratin 5 (CK5) (R) [EP42] antibody is a rabbit monoclonal antibody raised for the detection of cytokeratin 5, a type II intermediate filament protein. CK5 is expressed in the active basal layers of most stratified squamous epithelia.15 CK5 has been identified as a specific immunohistochemical marker for lung squamous cell carcinoma (SqCC), with minimal […]
