![Tonsil stained with CD19 (RM) [RM332] antibody](https://biocare.net/wp-content/uploads/3270-1.jpg)
The Biocare CD19 antibody detects CD19, a transmembrane glycoprotein of the immunoglobulin superfamily encoded by the CD19 gene and regulated by the B-cell-specific activator protein (BSAP).15 CD19 is expressed across nearly all developmental and activation-dependent stages of B-cell differentiation and serves as a key regulator of antigendependent B-cell activation.15 It is expressed in various B-cell […]
![Tonsil stained with VISTA [BLR035F] antibody](https://biocare.net/wp-content/uploads/3271-1.jpg)
V-domain Ig-containing suppressor of T cell activation (VISTA), also known as PD-1H, is a member of the immunoglobulin (Ig) superfamily, whose extracellular domain bears homology to the B7 family ligand, particularly PDL1. VISTA is predominantly expressed on granulocytic, myeloid cells and T cells.15 VISTA expresses on T cells as a part of an inhibitory immune […]
Glucagon, a 29-amino acid peptide, is secreted from the α-cells in the pancreas and from the endocrine cells in the gastrointestinal tract.15 Glucagon-secreting alpha-cells and insulin-secreting beta-cells make up the majority of the endocrine cell population within the pancreatic islets, and they work together to maintain glucose homeostasis.16 Glucagon works by binding to its glucagon […]
NKX is a prostate-specific tumor suppressor gene and loss of a single allele may predispose to prostate carcinogenesis (1). Studies have shown that the onset of MYC overexpression and the subsequent development of prostatic intraepithelial neoplasia coincide with this reduction in NKX (2). Over-expression of MYC has been reported as an early oncogenic event driving […]
The PTEN del-TECT (4 Color) FISH probe greatly increases the reliability of deletion detection, significantly decreasing the number of falsepositive events2 caused by cell truncation, an artifact of FFPE tissue processing. The PTEN Test probe is labeled in Orange and detects deletions of the PTEN gene. Probe A (WAPAL/BMPR1A) is located centromeric to the test […]
![Tonsil stained with HLA-DR [TAL 1B5] antibody](https://biocare.net/wp-content/uploads/3273.jpg)
HLA-DR (Human Leukocyte Antigen – DR isotype) is a major histocompatibility complex (MHC) class II antigen presentation molecule, critical for the activation of lymphocytes and the coordinating of adaptive immune responses. HLA DR antigen is required for tumor-associated antigen recognition by CD4+ T cells. It is normally expressed on antigen-presenting cells including monocytes, macrophages, dendritic […]
![Spleen stained with Glycophorin A [JC159] antibody](https://biocare.net/wp-content/uploads/3272.jpg)
Glycophorin A, which is the major membrane sialoglycoprotein of human red cells and their precursors, is a specific and early marker for the normal erythroid lineage.15 Glycophorin A is expressed at all stages of erythroid differentiation that includes both nucleated and non-nucleated stages of differentiation. Glycophorin A is a very important diagnostic marker of acute […]
![Prostate stained with PSAP [rACCP/1338] antibody](https://biocare.net/wp-content/uploads/3263.jpg)
Prostate-specific acid phosphatase (PSAP) is an enzyme produced in prostate epithelial cells. PSAP expression levels proportionally increase with prostate cancer progression.15 PSAP IHC staining is often used in conjunction with prostate specific antigen (PSA) staining to help distinguish poorly differentiated carcinomas. For instance, PSAP is commonly used to help differentiate prostate adenocarcinoma and urothelial carcinoma […]
![Breast carcinoma stained with PCNA [PC10] antibody](https://biocare.net/wp-content/uploads/3255.jpg)
Proliferating cell nuclear antigen (PCNA) is necessary for DNA synthesis and is an accessory protein for DNA polymerase alpha, which is elevated during the G1/S phase of the cell cycle. PCNA forms a ring around a portion of DNA, serving to anchor the various DNA replication and repair proteins and to regulate proliferation throughout the […]
![Melanoma stained with PRAME [EPR20330] antibody](https://biocare.net/wp-content/uploads/3252.jpg)
PRAME is located on chromosome 22q11.22 and encodes a 509 amino acid protein. PRAME is an autosomal cancer-testis antigen (CTA) gene which has been shown to be expressed in melanoma, various nonmelanocytic malignant neoplasms, including non-small cell lung cancer, breast carcinoma, renal cell carcinoma, ovarian carcinoma, leukemia, synovial sarcoma, and myxoid liposarcoma. Normal healthy tissues […]
