Uro-2 (CK20 + p53) is a primary antibody cocktail for the multiplex IHC identification of CK20 and p53 proteins in bladder. Studies have shown that in normal urothelium, the superficial umbrella cell layer shows reactivity for CK20 only; whereas, p53 nuclear staining is absent to focal. For urothelium with reactive atypia, particularly in cases with […]
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium.15-17
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
p63, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p63, catalog numbers CM163, PM163, IP163, VP163, OAI163 as a substitute. p63, 3X (Breast) [4A4] is comprised of a mouse monoclonal anti-p63 antibody. p63 is a transcription factor […]
p63, a homolog of the tumor suppressor p53, has been identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate.15 p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate.16 As […]
The Muscle Specific Actin antibody [HHF35] recognizes muscle specific alpha and gamma actin isomers. It does not react with non-muscle actin. Studies have shown that it recognizes the alpha actin from cardiac, skeletal and smooth muscle sources. It does not react with beta or non-smooth muscle gamma actin isomers. The antibody labels leiomyoma, leiomyosarcoma, angiomyolipoma […]
Chromosomal translocations involving the ETS transcription factors, such as ERG and ETV1, are frequent events in human prostate cancer pathogenesis. In particular, the TMPRSS2-ERG fusion gene has recently been found to be the most frequent gene rearrangement in prostate cancers, occurring in 45-65% of North American patients. Recent reports have demonstrated a strong correlation between […]
In human prostate cancer, the ERG oncogene is frequently overexpressed due to chromosomal translocations involving ERG and regulatory sequences of the TMPRSS2 or other androgen responsive genes. Recently, a mouse monoclonal anti-ERG antibody was developed with an unprecedented 99.9% specificity for detecting prostatic adenocarcinoma. The report shows strong correlation between the expression of the ERG […]
In human prostate cancer, the ERG oncogene is frequently overexpressed due to chromosomal translocations involving ERG and regulatory sequences of the TMPRSS2 or other androgen responsive genes. In particular, the TMPRSS2:ERG fusion gene has been found to be the most frequent gene rearrangement in prostate cancers, occurring in 45-65% of North American patients. A mouse […]
D2-40 reacts with an O-linked sialoglycoprotein (MW 40 kDa) found in lymphatic endothelium, fetal testis and on the surface of testicular germ-cell tumors. D2-40 is a new selective marker of lymphatic endothelium in normal tissues and vascular lesions. In recent studies, clone D2-40 has shown a staining reaction in lymphatic channel endothelium, but not in […]
