CK7/18, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer CK7 and CK18, catalog numbers CRM339, PRM339, IP339 and ACI3061, API3061 as a substitute. CK7/18, 3X (Breast) [BC1 and E431-1] is comprised of rabbit monoclonal anti-CK7 and anti-CK18 […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues. p63, a homolog of the tumor suppressor p53, was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. Expression of P504S protein is found […]
Uroplakin III is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. Uroplakin III [BC17] demonstrated a higher sensitivity compared with [AU1] on urothelial transitional cell carcinomas, in in-house studies. [BC17] staining was negative in all normal and neoplastic tissues except for bladder; hence it is highly specific to uroepithelial […]
Uroplakin II is a 15 kDa protein component of urothelial plaques, which enhance the permeability barrier of the urothelium. 15 Uroplakin II [BC21] is a highly specific antibody that may be useful in identifying tumors of urothelial origin.
CD44 + p53 + CK20 can be used to differentiate urothelial reactive atypia from CIS (carcinoma in situ) in bladders. In normal urothelium, superficial umbrella cell layer shows reactivity for CK20 only, whereas CD44 staining is limited to the basal and parabasal urothelial cells and p53 nuclear staining is absent to focal. For urothelium with […]
Uro-2 (CK20 + p53) is a primary antibody cocktail for the multiplex IHC identification of CK20 and p53 proteins in bladder. Studies have shown that in normal urothelium, the superficial umbrella cell layer shows reactivity for CK20 only; whereas, p53 nuclear staining is absent to focal. For urothelium with reactive atypia, particularly in cases with […]
Thyroid transcription factor-1 (TTF-1) is a member of the NKX2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and lung. TTF-1 has been shown to be a sensitive (65-81%) and specific marker (94%) in the majority of primary lung adenocarcinomas. Studies have shown that TTF-1, used in combination […]
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium.15-17
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
p63, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p63, catalog numbers CM163, PM163, IP163, VP163, OAI163 as a substitute. p63, 3X (Breast) [4A4] is comprised of a mouse monoclonal anti-p63 antibody. p63 is a transcription factor […]
