Cytokeratin 5/6 reacts with human epidermis and nonkeratinizing epithelium as determined by immunoblotting. It also reacts with cytokeratin No. 6 and weakly reacts with cytokeratin No. 4. It does not react with cytokeratin 1, 7, 8, 10, 13, 14, 18 and 19.15
Cytokeratin 5/14 Cocktail, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5/14 Cocktail, catalog numbers ACI3025 & API3025 as a substitute. CK5 [XM26] has been shown to have positive reactivity for CK5 protein and lack of reactivity […]
CK5 is distributed in many non-keratinizing stratified squamous epithelia such as tongue mucosa, basal epithelia, hair follicles, trachea, as well as basal cells in prostate glands and myoepithelial cells in mammary glands.15-19 CK5 is also expressed in most epithelial and biphasic mesotheliomas. CK5 has also been noted in large cell carcinomas and pulmonary squamous cell […]
The Cytokeratin 5 (CK5) (R) [EP42] antibody is a rabbit monoclonal antibody raised for the detection of cytokeratin 5, a type II intermediate filament protein. CK5 is expressed in the active basal layers of most stratified squamous epithelia.15 CK5 has been identified as a specific immunohistochemical marker for lung squamous cell carcinoma (SqCC), with minimal […]
CK5 is a 58 kDa protein that is closely related to CK6.15 ELISA was carried out to screen for antibodies that were positive for CK5 and negative with CK6. Results showed that the XM26 clone was positive for CK5 protein and was negative for the CK6 protein. CK5 tissue distribution is in many nonkeratinizing stratified […]
Cytokeratin 20 is 46 kDa intermediate filament protein that has been identified with expression primarily restricted to gastric and intestinal epithelium, urothelium, and Merkel cells. Cytokeratin 20 has been shown as a unique type I keratin that is expressed in adenocarcinomas of the colon, stomach, pancreas and bile system.15,16
Cytokeratin 19 antibody reacts with the rod domain of human keratin 19, a 40kDa polypeptide. The antibody reacts with MCF-7 cells and has been shown to label trichoblastoma, thyroid tumors, oral cancer, and epithelial odontogenic tumors. CK19 is not expressed in most hepatocytes, therefore cytokeratin 19 is useful in the identification of liver metastasis and […]
Cytokeratin 18 (CK18) is a 45 kDa acidic intermediate filament protein. It is normally coexpressed with cytokeratin 8 and is found in most simple ductal and glandular epithelia.15 The antibody reacts with a wide variety of neoplastic tissues such as gastrointestinal tract, lung, and breast tumors;16-18 whereas tumor cells of nonepithelial origin such as glioma, […]
This antibody reacts with a human intermediate filament protein of 50 kDa, known as Cytokeratin 14 antibody. Studies have shown that it can be used to distinguish stratified epithelial cells from simple epithelial cells. In neoplastic cells, CK14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. […]
The Biocare Cytokeratin 7 [BC1] antibody detects cytokeratin 7, a 54 kDa intermediate filament protein expressed in simple epithelia of most glandular and transitional tissues, but not in stratified squamous epithelia.15-17 This rabbit monoclonal antibody is highly specific for cytokeratin 7 and does not cross react with other intermediate filament proteins. Cytokeratin 7 is expressed […]
