Carbonic anhydrase 9 (CA-9) is a transmembrane zinc metalloenzyme which has a function in cell-cell adhesion and plays an important role in tumor growth and survival under normoxia and hypoxia.15 Upregulation of CA-9 in tumors is an effective adaptive response to hypoxia and increases the tumor cell survival.16 CA-9 expression is mostly restricted to the […]
The OCT 3/4 transcription factor, a member of the POU family, is expressed in totipotent embryonic stem cells (ES) and germ cells.15 OCT 3/4 has a unique role in development and in the determination of pluripotency.15 OCT 3/4 immunohistochemistry staining has been shown to be a useful marker for a wide variety of gonadal and […]
PBX1 (1q23.3) Orange FISH Probe is intended to hybridize to the 1q23.3 probe region on chromosome 1. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
Antigen Retrieval 3 (AR3) is capable of partially breaking the covalent bonds of formalin-fixed tissue, as part of an ISH staining procedure on the ONCORE Pro Automated Slide Stainer. Pretreatment of FFPE tissues with Antigen Retrieval 3 (AR3) can increase staining intensity. Probe Enhancer (RNA) is an ancillary hybridization reagent that promotes spreading and reduces […]
The ONCORE Pro-Tect Detection Kit is designed using a two-step or threestep method for detecting mouse and/or rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the two-step method (rabbit), the universal linker is applied, then an additional enzyme-linked polymer labeled reagent is sequentially applied. In […]
![Uterus stained with Mast Cell Tryptase [AA1] antibody](https://biocare.net/wp-content/uploads/3277.jpg)
Mast Cell Tryptase, also known as Tryptase, is a serine protease predominantly produced and stored in mast cells. It has been studied for its involvement in biological processes such as tissue remodeling and angiogenesis.15,16 According to published literature, mast cells expressing Tryptase have been observed in a variety of human tissues, including those from hematologic […]
CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), can hydrolyze extracellular ATP and ADP. It is one of the key enzymes in the adenosine pathway and targeted adenosine may play a role in antitumor strategies.15 CD39 pathway inhibits natural killer (NK) cells and promotes the metastasis of tumors.15 Overexpression of CD39 has been observed […]
This antibody recognizes a protein of 185 kDa, identified as the second member (cerbB-2/HER-2) of the c-erbB family.5,6 This rabbit monoclonal antibody is directed against the cytoplasmic domain of the human c-erbB-2 protein. The c-erbB-2 is closely related in structure to the epidermal growth factor receptor.6 The c-erbB-2 protein is overexpressed in a variety of […]
![Colon cancer stained with SATB2 [CL0323] antibody](https://biocare.net/wp-content/uploads/3259-SATB2.jpg)
SATB2 (special AT-rich sequence binding 2) is a human DNA-binding protein involved in transcriptional regulation and chromatin remodeling.15,16 SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract including appendix, colon and rectum. SATB2 protein expression was also found in non–germinal center lymphoid cells, and the ductal epithelium […]
TRBC1 is a rabbit polyclonal antibody that is intended for laboratory use after the initial diagnosis of tumor has been made by conventional histopathology using nonimmunologic histochemical stains, in the qualitative identification of TRBC1 protein by immunohistochemistry (IHC) in formalin-fixed paraffinembedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be […]
