The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 is expressed in multipotent neuronal stem cells, and may aid to identify cells that are capable of self-renewal and multipotent differentiation (1-3). SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, […]
NKX is a prostate-specific tumor suppressor gene and loss of a single allele may predispose to prostate carcinogenesis1. Studies have shown that the onset of MYC over expression and the subsequent development of prostatic intraepithelial neoplasia coincide with this reduction in NKX2 . Over-expression of MYC has been reported as an early oncogenic event driving […]
The process of ion-exchange was first observed by a British chemist in 1850. Ion-exchange is a process, by which one type of ion is absorbed into a solid material and replaced by an equivalent quantity of another ion of the same charge. By using this process, we have formulated an advanced decalcification system that removes […]
Universal Decloaker buffer solution with color-coded pH indicator is used for antigen retrieval methods. This solution allows the user to deparaffinize and pretreat tissues in two steps. It is used in conjunction with a Biocare’s Aqua DePar and an electric pressure cooker (Decloaking Chamber). Universal Decloaker is non-toxic, non-flammable and odorless. Xylene and alcohols are […]
Borg Decloaker (Borg), with color-coded pH indicator, can be used for traditional heat induced antigen retrieval (following deparaffinization in xylenes), or as part of a two step aqueous procedure for deparaffinization and retrieval, when used in conjunction with Biocare’s Aqua DePar or Hot Rinse and an electric pressure cooker (Decloaking Chamber). In the aqueous deparaffinization […]
Topoisomerase II alpha (Topo IIa) plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor […]
Smooth Muscle-Myosin Heavy Chain (SM-MHC) is a cytoplasmic structural protein that is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early and is specific for smooth muscle development.15
Renal cell carcinoma antibody (RCC), also known as a gurnistical tumor, is a common form of adult kidney cancer localized to the tubule linings of the kidney. The prognosis for advanced RCC is poor due to its resistant to chemotherapy and radiation therapy. The RCC clone 66.4.C2 is a monoclonal antibody raised against a 200 […]
PCNA [PC10], catalog number CM152B, is being discontinued. We will continue to offer this product until 06/30/16 or until current inventory is depleted, whichever occurs first. While no direct replacement is available, other cell proliferation markers we offer include Ki-67 and pHH3. Ki-67 is expressed in the nucleus during the whole cell cycle, except in […]
Pan Lymphoma Cocktail (LCA + CD20 + CD3 + CD43) are specific leukocyte markers used in the identification and assessment of lymphoid neoplasms. This combination of antibodies offers a marker for the identification of a variety of leukocytes. CD45 also known as leucocyte common antigen (LCA), is expressed on hematopoietic cell lines, but absent on […]
