Studies have shown CD45 recognizes an antigen found on lymphoid cells. Most neoplastic B-cells and T-cells stain positively in leukemia and in non Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative.15-17
Ki-67 + Caspase-3 can provide information on cell death vs. cell proliferation in the same tissue section. The Ki-67 nuclear antigen is associated with cell proliferation and is used to grade proliferation rates of tumors. Ki-67 is found throughout the cell cycle that includes the G1, S, G2, and M phases; but not the G0 […]
Glypican-3 (GPC3), a member of the glypican family of glycosyl phosphatidylinositol-anchored cell-surface heparin sulfate proteoglycans, plays an important role in cell growth and differentiation.15 Using the 1G12 monoclonal antibody, GPC3 has been identified as a useful tumor marker for the diagnosis of Hepatocellular Carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms’ tumor.15-18
E-Cadherin, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer E-cadherin (RM), catalog numbers ACI3012, API3012 as a substitute. E-cadherin is a transmembrane glycoprotein that plays a key role in cell-cell adhesion in epithelial tissues (1-2). The adherens junction […]
Immunohistochemical studies have shown E-cadherin antibody to be expressed in breast ductal carcinoma with loss of expression in lobular carcinoma. As a result, mouse monoclonal anti-E-cadherin [HECD-1] has been used by pathologists to differentiate between ductal and lobular carcinomas of the breast, with currently published sensitivity and specificity of approximately 90%. A rabbit monoclonal E-cadherin […]
E-cadherin is a transmembrane glycoprotein that mediates epithelial cell-to cell adhesion. The loss of E-cadherin can result in the disruption of cell clusters.15 It is therefore, postulated that E-cadherin may function as a tumor suppressor protein. The loss of E-cadherin has been associated with metastasis and poor prognosis in invasive breast cancer and can help […]
CD44 is a transmembranous glycoprotein (80 kDa) responsible for cell adhesion that is expressed in a wide range of normal tissues, such as tonsil, breast, prostate, skin, bladder and cervical squamous epithelium (1). Studies have shown that CD44, also known as HCAM, plays an important role in the cascade of metastasis and progression of human […]
CD31 recognizes a 100kDA glycoprotein in endothelial cells and 130kD in platelets. It reacts weakly with mantle zone B-cells, peripheral T-cells, and neutrophils.15 CD31 can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow.15-17 CD31 can […]
It has been shown that CD31 PECAM-1 Antibody can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow. When compared to Factor VIII and CD34 antibodies, studies have shown CD31 to be a superior marker for […]
The causative bacterial agent of cat scratch disease has been identified as Bartonella henselae. In the past, complicated silver stains and/or PCR were used to identify and confirm this agent. This monoclonal Cat Scratch antibody aids to identify Bartonella henselae in formalin-fixed, paraffin-embedded (FFPE) tissues. Cross-reactivity tests were performed on 12 Bartonella henselae strains, 11 […]
