Mar
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
![Liver cancer stained with CD47 [EPR21794] antibody](https://biocare.net/wp-content/uploads/3284.jpg)
Sep
CD47 has been shown to have a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.15 In the brain, it appears to play an important role in memory formation and synaptic plasticity in the hippocampus.16 CD47 is a receptor for SIRPA, binding to […]
![Colon cancer stained with SATB2 [CL0323] antibody](https://biocare.net/wp-content/uploads/3259-SATB2.jpg)
Jun
SATB2 (special AT-rich sequence binding 2) is a human DNA-binding protein involved in transcriptional regulation and chromatin remodeling.15,16 SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract including appendix, colon and rectum. SATB2 protein expression was also found in non–germinal center lymphoid cells, and the ductal epithelium […]
![Tonsil stained with VISTA [BLR035F] antibody](https://biocare.net/wp-content/uploads/3271-1.jpg)
Apr
V-domain Ig-containing suppressor of T cell activation (VISTA), also known as PD-1H, is a member of the immunoglobulin (Ig) superfamily, whose extracellular domain bears homology to the B7 family ligand, particularly PDL1. VISTA is predominantly expressed on granulocytic, myeloid cells and T cells.15 VISTA expresses on T cells as a part of an inhibitory immune […]
Apr
Glucagon, a 29-amino acid peptide, is secreted from the α-cells in the pancreas and from the endocrine cells in the gastrointestinal tract.15 Glucagon-secreting alpha-cells and insulin-secreting beta-cells make up the majority of the endocrine cell population within the pancreatic islets, and they work together to maintain glucose homeostasis.16 Glucagon works by binding to its glucagon […]
Mar
The MYC gene belongs to a family of transcription factors that under normal conditions it controls cell cycle progression (1). However, in multiple types of cancer, MYC is considered a Proto-oncogene (1). MYC gene deregulation is identified in multiple malignancies such as Burkitt’s lymphoma, diffuse large B-cell lymphoma, and B-cell lymphoma (2). MYC gene amplifications, […]
![Ovarian cancer stained with H3K27me3 [C36B11] antibody](https://biocare.net/wp-content/uploads/3249-1.jpg)
Apr
H3K27me3 (histone 3 lysine 27 trimethylation) is an epigenetic mark that plays a critical role in regulation of gene expression. The dysregulation of H3K27me3 is implicated in the genesis and progression of cancer. Studies indicate that H3K27me3 plays a role in the creation and maintenance of cell type-specific programs of transcriptional control for a wide […]
![Solitary fibrous tumor stained with STAT6 [YE361] antibody](https://biocare.net/wp-content/uploads/3244.jpg)
Jan
STAT6 (signal transducer and activator of transcription 6) is a member of the STAT family of cytoplasmic transcription factors, which regulate gene expression by transmitting signals to the nucleus and binding to specific DNA promoter sequences. STAT6 is composed of a DNA-binding domain, a C-terminal transcriptional activation domain, and a SH2 domain. STAT signaling is […]
