Fast Red is a well-established chromogen used in IHC staining protocols that in the presence of an alkaline phosphatase (AP) enzyme, produces a bright fuchsin-red precipitate that is insoluble in organic solvents and can be coverslipped with a permanent mounting media. ONCORE Pro Warp Red Chromogen Kit contains two solutions: Warp Red Chromogen and the […]
The Rabbit Amp AP Detection is designed using a one-step method for detecting Rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the one-step method a secondary antibody directly linked to the micropolymer is applied. Rabbit Amp AP Detection is provided ready-to-use and is intended to […]
Immunoglobulin lambda light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Lambda Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human lambda light chain mRNA.
The Epstein – Barr virus is a member of the gamma-herpes viruses (HHV-4). Epstein-Barr Encoded (EBER) Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind EBER-1 and EBER-2 mRNA sequences that may be expressed in latently infected cells.1
Immunoglobulin kappa light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Kappa Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human kappa light chain mRNA.
![Tonsil stained with CD20 [BC30] antibody](https://biocare.net/wp-content/uploads/3287.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B-cell lymphoma cells making […]
![Tonsil stained with Hairy Cell Leukemia [DBA.44] antibody](https://biocare.net/wp-content/uploads/3279.jpg)
Hairy Cell Leukemia is a rare hematological malignancy in which B-cell lymphocytes are produced in excessive quantities. Hairy Cell Leukemia is characterized by small lymphocytes bearing fine hair-like cytoplasmic projections with infiltration of reticuloendothelial organs such as lymphoid organs and bone marrow.15,16 This mouse monoclonal antibody, also referred to as DBA.44, may be used in […]
Carbonic anhydrase 9 (CA-9) is a transmembrane zinc metalloenzyme which has a function in cell-cell adhesion and plays an important role in tumor growth and survival under normoxia and hypoxia.15 Upregulation of CA-9 in tumors is an effective adaptive response to hypoxia and increases the tumor cell survival.16 CA-9 expression is mostly restricted to the […]
The OCT 3/4 transcription factor, a member of the POU family, is expressed in totipotent embryonic stem cells (ES) and germ cells.15 OCT 3/4 has a unique role in development and in the determination of pluripotency.15 OCT 3/4 immunohistochemistry staining has been shown to be a useful marker for a wide variety of gonadal and […]
Research has shown that deletions of PTEN occur at a very high frequency in prostate cancer (1). Other studies have demonstrated an association between decreased PTEN protein expression and a higher Gleason grade and advanced tumor stage (2). In a study by Yoshimoto, it was demonstrated that the presence of PTEN genomic losses are frequent […]
