p27 KIP1 is a member of the Cyclin Inhibitory Protein/Kinase Inhibitory Protein (CIP/KIP) family of cyclin-dependent kinase (Cdk) inhibitors.15 It plays roles in all phases of the cell division cycle. Thus, important cellular functions as the cell division cycle, respiration, RNA processing, translation, and cell adhesion, are under p27 KIP1 regulation.15 Reduced levels of p27 […]
The Mouse Amp AP Detection is intended for use in automated Immunohistochemistry (IHC) staining protocols using an alkaline phosphatase (AP) polymer one-step application method. This micro-polymer detection kit is designed for the detection of mouse IgG and IgM primary antibodies bound to target antigens in the formalin-fixed, paraffin-embedded (FFPE) tissues during the IHC staining process. […]
Fast Red is a well-established chromogen used in IHC staining protocols that in the presence of an alkaline phosphatase (AP) enzyme, produces a bright fuchsin-red precipitate that is insoluble in organic solvents and can be coverslipped with a permanent mounting media. ONCORE Pro Warp Red Chromogen Kit contains two solutions: Warp Red Chromogen and the […]
The Rabbit Amp AP Detection is designed using a one-step method for detecting Rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the one-step method a secondary antibody directly linked to the micropolymer is applied. Rabbit Amp AP Detection is provided ready-to-use and is intended to […]
Immunoglobulin lambda light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Lambda Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human lambda light chain mRNA.
The Epstein – Barr virus is a member of the gamma-herpes viruses (HHV-4). Epstein-Barr Encoded (EBER) Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind EBER-1 and EBER-2 mRNA sequences that may be expressed in latently infected cells.1
Immunoglobulin kappa light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Kappa Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human kappa light chain mRNA.
![Tonsil stained with CD20 [BC30] antibody](https://biocare.net/wp-content/uploads/3287.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B-cell lymphoma cells making […]
![Tonsil stained with Hairy Cell Leukemia [DBA.44] antibody](https://biocare.net/wp-content/uploads/3279.jpg)
Hairy Cell Leukemia is a rare hematological malignancy in which B-cell lymphocytes are produced in excessive quantities. Hairy Cell Leukemia is characterized by small lymphocytes bearing fine hair-like cytoplasmic projections with infiltration of reticuloendothelial organs such as lymphoid organs and bone marrow.15,16 This mouse monoclonal antibody, also referred to as DBA.44, may be used in […]
Carbonic anhydrase 9 (CA-9) is a transmembrane zinc metalloenzyme which has a function in cell-cell adhesion and plays an important role in tumor growth and survival under normoxia and hypoxia.15 Upregulation of CA-9 in tumors is an effective adaptive response to hypoxia and increases the tumor cell survival.16 CA-9 expression is mostly restricted to the […]
