Early on, Biocare recognized the market need for evaluating morphologically distinct markers to aid in solving complex clinical problems and simplifying interpretation, all while conserving precious patient tissue. The most glaring clinical need was determined to be the ability to differentiate between prostatic intraepithelial neoplasia (PIN) and carcinoma of the prostate. There also needed to […]
Sep
A monoclonal antibody cocktail targeted against mini-chromosome maintenance protein 2 (MCM2) and DNA topoisomerase IIA (TOP2A), when up regulated, serves as a marker of aberrant S-phase induction in proliferating cells.15 MCM2, as part of a hexameric pre-replication complex, drives the formation of pre-replicative complexes during DNA replication, a critical initial step during G1 phase.16 TOP2A […]
Mar
Clones EP17 and EP30 recognize cytokeratins (CK) 8 and 18, both of which are low molecular weight intermediate filament proteins (52.5 kDa and 45 kDa respectively). In normal tissues, CK8/18 recognizes all simple and glandular epithelium (1). In neoplastic tissues, CK8/18 may prove useful for the identification of most adenocarcinomas and some squamous cell carcinomas. […]
Carcinoembryonic Antigen Carcinoembryonic Antigen (CEA {P}) CDX2 Cytokeratin 20 D2-40 DOG1 Helicobacter pylori Ki-67 (M) Ki-67 MLH-1 MSH2 MSH6 Mucin 5AC p53 Pan Cytokeratin [AE1/AE3] Pan Cytokeratin [Lu-5] Pan Cytokeratin Plus [AE1/AE3 + 8/18] PMS2 Villin CDX2 + CK7 D2-40 + CD31 D2-40 + Ki-67
Beta-Catenin Calponin c-erB-2/HER2 Cytokeratin 7 E-cadherin (Mouse) E-Cadherin Estrogen Receptor (ER) [6F11] Estrogen Receptor (ER) [SP1] Folate Receptor alpha IHC Assay Kit Gross Cystic Disease Fluid Protein-15 Ki-67 (M) Mammaglobin p53 p63 p40 (M) Phospho-Histone H3 Progesterone Receptor (PR) [PgR636] Progesterone Receptor (PR) [SP2] PTEN (Tumor Suppressor) Estrogen Receptor (ER) [6F11 + SP1] CK5/14 + […]
Apr
p53 (RM), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p53, catalog numbers CME298, PME298, IP298 as a substitute. The tumor suppressor p53 plays a key role in regulating urothelial growth and genomic stability. Increased expression of p53 […]
