![Uterus stained with Mast Cell Tryptase [AA1] antibody](https://biocare.net/wp-content/uploads/3277.jpg)
Mast Cell Tryptase, also known as Tryptase, is a serine protease predominantly produced and stored in mast cells. It has been studied for its involvement in biological processes such as tissue remodeling and angiogenesis.15,16 According to published literature, mast cells expressing Tryptase have been observed in a variety of human tissues, including those from hematologic […]
![Liver cancer stained with CD47 [EPR21794] antibody](https://biocare.net/wp-content/uploads/3284.jpg)
CD47 has been shown to have a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.15 In the brain, it appears to play an important role in memory formation and synaptic plasticity in the hippocampus.16 CD47 is a receptor for SIRPA, binding to […]
CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), can hydrolyze extracellular ATP and ADP. It is one of the key enzymes in the adenosine pathway and targeted adenosine may play a role in antitumor strategies.15 CD39 pathway inhibits natural killer (NK) cells and promotes the metastasis of tumors.15 Overexpression of CD39 has been observed […]
This antibody recognizes a protein of 185 kDa, identified as the second member (cerbB-2/HER-2) of the c-erbB family.5,6 This rabbit monoclonal antibody is directed against the cytoplasmic domain of the human c-erbB-2 protein. The c-erbB-2 is closely related in structure to the epidermal growth factor receptor.6 The c-erbB-2 protein is overexpressed in a variety of […]
![Colon cancer stained with SATB2 [CL0323] antibody](https://biocare.net/wp-content/uploads/3259-SATB2.jpg)
SATB2 (special AT-rich sequence binding 2) is a human DNA-binding protein involved in transcriptional regulation and chromatin remodeling.15,16 SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract including appendix, colon and rectum. SATB2 protein expression was also found in non–germinal center lymphoid cells, and the ductal epithelium […]
TRBC1 is a rabbit polyclonal antibody that is intended for laboratory use after the initial diagnosis of tumor has been made by conventional histopathology using nonimmunologic histochemical stains, in the qualitative identification of TRBC1 protein by immunohistochemistry (IHC) in formalin-fixed paraffinembedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be […]
NPM1 is a rabbit polyclonal antibody that is intended for laboratory use after the initial diagnosis of tumor has been made by conventional histopathology using nonimmunologic histochemical stains, in the qualitative identification of NPM1 protein by immunohistochemistry (IHC) in formalin-fixed paraffinembedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be […]
![Tonsil stained with CD19 (RM) [RM332] antibody](https://biocare.net/wp-content/uploads/3270-1.jpg)
The Biocare CD19 antibody detects CD19, a transmembrane glycoprotein of the immunoglobulin superfamily encoded by the CD19 gene and regulated by the B-cell-specific activator protein (BSAP).15 CD19 is expressed across nearly all developmental and activation-dependent stages of B-cell differentiation and serves as a key regulator of antigendependent B-cell activation.15 It is expressed in various B-cell […]
![Tonsil stained with VISTA [BLR035F] antibody](https://biocare.net/wp-content/uploads/3271-1.jpg)
V-domain Ig-containing suppressor of T cell activation (VISTA), also known as PD-1H, is a member of the immunoglobulin (Ig) superfamily, whose extracellular domain bears homology to the B7 family ligand, particularly PDL1. VISTA is predominantly expressed on granulocytic, myeloid cells and T cells.15 VISTA expresses on T cells as a part of an inhibitory immune […]
Glucagon, a 29-amino acid peptide, is secreted from the α-cells in the pancreas and from the endocrine cells in the gastrointestinal tract.15 Glucagon-secreting alpha-cells and insulin-secreting beta-cells make up the majority of the endocrine cell population within the pancreatic islets, and they work together to maintain glucose homeostasis.16 Glucagon works by binding to its glucagon […]
