High molecular weight cytokeratins are expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate, CK HMW [34βE12] has been shown to be a useful marker of basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; whereas invasive prostatic adenocarcinoma typically lacks a basal cell […]
p53 (RM), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p53, catalog numbers CME298, PME298, IP298 as a substitute. The tumor suppressor p53 plays a key role in regulating urothelial growth and genomic stability. Increased expression of p53 […]
CK20, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 20, catalog numbers CM062, PM062, IP062, OAI062 as a substitute. Cytokeratin 20 (CK20 antibody) is an intermediate filament protein that has been identified with expression primarily restricted to […]
p63 has been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with reported sensitivities of 80-100% (1-6). Specificity for lung SqCC, versus lung adenocarcinoma (LADC), has been reported to be approximately 70-90%, as positive staining with p63 has been typically observed in 10-30% of LADC (1-6). Cocktails of p63 with complementary […]
CK5/14, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5/14 Cocktail, catalog numbers ACI3025, API3025 as a substitute. CK5/14, 3X antibody (Breast) [XM26 and LL002] is comprised of mouse monoclonal anti-CK5 and anti-CK14 antibodies. CK5 and […]
CK7/18, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer CK7 and CK18, catalog numbers CRM339, PRM339, IP339 and ACI3061, API3061 as a substitute. CK7/18, 3X (Breast) [BC1 and E431-1] is comprised of rabbit monoclonal anti-CK7 and anti-CK18 […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues. p63, a homolog of the tumor suppressor p53, was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. Expression of P504S protein is found […]
Uroplakin III is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. Uroplakin III [BC17] demonstrated a higher sensitivity compared with [AU1] on urothelial transitional cell carcinomas, in in-house studies. [BC17] staining was negative in all normal and neoplastic tissues except for bladder; hence it is highly specific to uroepithelial […]
Uroplakin II is a 15 kDa protein component of urothelial plaques, which enhance the permeability barrier of the urothelium. 15 Uroplakin II [BC21] is a highly specific antibody that may be useful in identifying tumors of urothelial origin.
CD44 + p53 + CK20 can be used to differentiate urothelial reactive atypia from CIS (carcinoma in situ) in bladders. In normal urothelium, superficial umbrella cell layer shows reactivity for CK20 only, whereas CD44 staining is limited to the basal and parabasal urothelial cells and p53 nuclear staining is absent to focal. For urothelium with […]
