TP53 is the gene which encodes for the p53 tumor suppressor protein. TP53 is activated in many forms of cellular stress including carcinogensis and exerts multiple anti-proliferatiuve functions1. TP53 mutations are one of the most common findings in many human cancers and has been proposed as an effective measure of prognosis2. Typically the prescence of […]
Loss of the 13q region or even the whole of chromosome 13 is very common in cases of multiple myeloma (MM). Deletions of the DS13S319 gene are common in a variety of hematological malignancies including chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML) and MM1,2. FOR DISTRIBUTION OUTSIDE THE UNITED STATES ONLY
HPV Type 51 Probe is a digoxigenin-labeled DNA probe designed to hybridize to HPV Type 51 DNA sequences. HPV Type 51 Probe is provided in DNA Hybridization Buffer (BRI4036) containing dextran sulfate, nucleic acid carriers and formamide.
The 5p15.2 Red FISH Probe is a fluorescently labeled probe designed to hybridize to ~353 kb of the 5p15.2 region of chromosome 5. 5p15.2 Red probe (40-100 ng/µl) is provided in FISH Hybridization Buffer (FRR7311A) containing dextran sulfate and formamide.
Cervical cancer is one of the most common cancers affecting women worldwide. The implementation of cytogenetic based screening techniques has greatly reduced the incidence and mortality of cervical cancer in the United States 1. Moreover, traditional screening methods such as Pap smears and human papillomavirus (HPV) based testing are utilized to stratify and identify patients […]
HPV Type 51 Probe (0.1 mL) is a biotin-labeled DNA probe designed to hybridize to HPV Type 51 DNA sequences. HPV Type 51 Probe (5-50 ng/mL) is provided in DNA Hybridization Buffer (BRI4036) containing dextran sulfate, nucleic acid carriers and formamide.
CD11c (also known as Leu-M5 or Integrin alpha X) [5D11] is a member of the leukointegrin family. CD11c is a cell surface adhesion receptor and is predominantly expressed in tissue macrophages, dendritic cells, monocytes, NK cells and granulocytes. CD11c has been shown to be both sensitive and specific for hairy cell leukemia (HCL) (1). CD11c […]
TP53 (Tumor protein 53) is a DNA-binding protein that activates expression of genes that inhibit growth, functioning as a tumor suppressor¹. It is a gatekeeper gene whose function is to control the cell cycle and apoptosis. Inactivation of TP53 leads to deregulation of cell cycle control and continued cell survival². The TP53 test probe labeled […]
The RREB1 (6p25) single color CLEAR-VIEW FISH™ probe is directly labelled in CYMO-ORANGE and is designed to detect copy number alterations of RREB1 on chromosome 6. The RREB1 probe is ~661 KB and spans the RREB1 gene. A normal nucleus will show two orange signals.
The 5p15.2 CLEAR-VIEW FISH™ direct labeled probe is ~353kb in size, located on chromosome 5p15.2 and spans the CTNND2 gene. The 5p15 FISH probe is labeled in CYMO-RED and detects copy numbers of the chr5p15 region. A normal cell will show two red signals.
