![Colon cancer stained with Pan Cytokeratin [Lu-5] antibody](https://biocare.net/wp-content/uploads/lw.jpg)
Pan Cytokeratin [Lu-5] antibody is has been demonstrated as a useful marker for the differentiation of epithelial and mesothelial cells from mesenchymal cells in normal and tumor tissues. It has been shown to serve as a first-order pan cytokeratin antibody for both acidic (type I) and basic (type II) cytokeratin subfamilies of all vertebrates tested […]
![Colon cancer stained with Pan Cytokeratin [AE1/AE3] antibody.](https://biocare.net/wp-content/uploads/011-2.jpg)
AE1/AE3 recognizes the acidic and basic (Type I and II) subfamilies of cytokeratins. The cocktail of these two antibodies can be used to detect most human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48, 46, 45, and 40 kDa. The basic cytokeratins have molecular weights of 65-67, 64, 59, […]
Pan Cytokeratin antibody Plus is a combination of [AE1/AE3] and Cytokeratin (CK) 8/18 [5D3] and can be used to detect most human epithelia. [AE1/AE3] recognizes acidic and basic subfamilies of cytokeratins, with molecular weights ranging from 40 to 67 kDa. CK8/18 [5D3] recognizes Cytokeratin 8 and 18 intermediate filament proteins. In normal tissues, [5D3] recognizes […]
p120 Catenin, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p120 Catenin, catalog numbers ACI3008, API3008 as a substitute. p120 catenin plays a role in cytoskeletal anchoring in the adherens junctions between epithelial cells (1-2). In normal tissues, […]
p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. The expression of p120 has been statistically correlated with the proliferation capacity in human lung cancer cells and could be a prognostic marker for resected Stage I lung adenocarcinoma.15-21
Diagnostic reproducibility of lobular vs. ductal lesions, based on histology alone, is less than optimal. The proper distinction between atypical lobular hyperplasia, lobular carcinoma in situ and low-grade ductal carcinoma in situ is critical for patient management. Studies have shown E-cadherin, a negative membrane marker for lobular neoplasia, is useful in the distinction of ductal […]
![Skin stained with Cytokeratin [AE1] LMW Antibody](https://biocare.net/wp-content/uploads/081.jpg)
The Biocare Cytokeratin AE1 antibody recognizes the acidic (type I) subfamilies of cytokeratins. These acidic cytokeratins have molecular weights of 56.5, 50, 50, 48, and 40 kDa (corresponding to cytokeratins 10, 14, 15, 16, and 19). Studies have shown AE1 to be useful for marking tumors such as squamous cell carcinoma and adenocarcinoma of the […]
Clone 5D3 recognizes cytokeratin (CK) 8 and 18 intermediate filament proteins. These are 52.5 kDa and 45 kDa respectively. In normal tissues, 5D3 recognizes all simple and glandular epithelium.15-16 In neoplastic tissues, 5D3 may prove useful for the identification of adenocarcinomas and some squamous cell carcinomas.15 Use in conjunction with HMW CK to rule out […]
![Lung (L) and Prostate (R) stained with Cytokeratin HMW [34βE12]](https://biocare.net/wp-content/uploads/1112.jpg)
34βE12 recognizes cytokeratins (CK) 1, 5, 10 and 14. This antibody is reactive with squamous and adeno-squamous carcinomas; adenocarcinomas are negative.15,16
CK17 antibody reacts with a 40kDa polypeptide and CK17 is a type I keratin. Studies have shown that it is indicated as an excellent marker for the identification of squamous cell carcinomas in various tissues including the cervix, lung, and oral cavity.18 CK17 may be helpful to aid in distinguishing myoepithelial cells from luminal epithelium […]
