This rabbit monoclonal antibody recognizes a protein of 36 kDa, identified as Cyclin D1 (also known as Bcl-1 or PRAD-1). Cyclin D1 is a regulatory subunit of certain protein kinases thought to advance the G1 phase of the cell cycle.15 Cyclin D1 used in tandem with CD5, CD10 and CD23 is the most reliable immunohistochemical […]
Cyclooxygenase (COX-2) is an inducible enzyme involved in production of prostaglandins in inflammatory processes. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX-2 is therefore of interest in studying immune response regulation. COX-2 is induced by a wide […]
This antibody reacts with type IV collagen, which is the major constituent of the basement membranes. Collagen IV antibody stains the basement membranes in a variety of tissues including kidney, muscle, lymph nodes, lung, tendon and spleen. Collagen IV has been shown to be useful in differentiating microinvasive from in situ ductal carcinomas of the […]
CD31 recognizes a 100kDA glycoprotein in endothelial cells and 130kD in platelets. It reacts weakly with mantle zone B-cells, peripheral T-cells, and neutrophils.15 CD31 can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow.15-17 CD31 can […]
It has been shown that CD31 PECAM-1 Antibody can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow. When compared to Factor VIII and CD34 antibodies, studies have shown CD31 to be a superior marker for […]
This antibody recognizes a protein of 185 kDa, identified as the second member (cerbB-2/HER-2) of the c-erbB family. This rabbit monoclonal antibody is directed against the cytoplasmic domain of the human c-erbB-2 protein. The c-erbB-2 is closely related in structure to the epidermal growth factor receptor.
Biotinylated Bromodeoxyuridine Antibody recognizes bromodeoxyuridine (BrdU), an analog to thymidine and can be incorporated into replicating DNA during the S-phase of the cell cycle. The BrdU antibody can be used for DNA labeling index, evaluation of DNA synthesis and cell proliferation studies. This antibody is biotinylated and thus eliminates the need for a biotinylated secondary […]
