![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![Spleen stained with HLA-B [BC43] antibody](https://biocare.net/wp-content/uploads/3289.jpg)
HLA-B is a highly polymorphic protein encoding gene for the major histocompatibility class I (MHC-I) complex.15 MHC class I molecules are expressed on the cell surface, binding and presenting antigenic peptides to CD8+ T lymphocytes to mediate immune responses against intracellular pathogens and cancers.16 Want to Learn More About HLA-B [BC43] Antibody? Download Our Complimentary […]
BCR (22q11.2) Green FISH Probe is intended to hybridize to the 22q11.2 probe region on chromosome 22. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
ABL (9q34.12) Orange FISH Probe is intended to hybridize to the 9q34.12 probe region on chromosome 9. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
CytoFISH products are now manufactured and sold by Empire Genomics, a Biocare Medical company. CytoFISH Multiplex probe is a cocktail of 4 individually fluorescently labeled probes: Copy Control 10 (green), Copy Control 7 (orange), Copy Control 3 (aqua), and 5p15.2 (red). Amplification at the 5p15.2 locus is strongly linked to high-grade, advanced-stage bladder tumors and […]
![Tonsil stained with HLA-DR [TAL 1B5] antibody](https://biocare.net/wp-content/uploads/3273.jpg)
HLA-DR (Human Leukocyte Antigen – DR isotype) is a major histocompatibility complex (MHC) class II antigen presentation molecule, critical for the activation of lymphocytes and the coordinating of adaptive immune responses. HLA DR antigen is required for tumor-associated antigen recognition by CD4+ T cells. It is normally expressed on antigen-presenting cells including monocytes, macrophages, dendritic […]
STAG1 is a component of cohesin, a ring-shaped protein complex involved in sister chromatid cohesion (SCC) that also plays important roles in the maintenance of chromatin structure, gene expression, and DNA repair. Cohesin consists of a core trimer and one of two mutually exclusive variant STAG subunits, STAG1 and STAG2. STAG1 is thought to primarily […]
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![Brain stained with Pan TRK [RM423] antibody](https://biocare.net/wp-content/uploads/3267.jpg)
The Biocare Pan TRK [RM423] rabbit monoclonal antibody targets the neurotrophic tyrosine receptor kinase (NTRK) proto-oncogenes. The NTRK proto-oncogenes NTRK1, NTRK2, and NTRK3 (that encode TRK A, TRK B, and TRK C proteins, respectively) may form gene fusions through their kinase domains, driving tumor development.15 TRK A is activated by nerve growth factor (NGF), TRK […]
![Tonsil stained with TIGIT [BC41] antibody](https://biocare.net/wp-content/uploads/3254.jpg)
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory domain (TIGIT) is a transmembrane glycoprotein receptor expressed in regulatory and memory T cells, natural killer (NK), and activated T cells (1). As a member of the immunoglobulin superfamily, TIGIT has coinhibitory effects on T-cell dependent immune responses, playing an important role in transplantation tolerance and tumor immune surveillance […]
