![Uterus stained with Mast Cell Tryptase [AA1] antibody](https://biocare.net/wp-content/uploads/3277.jpg)
Mast Cell Tryptase, also known as Tryptase, is a serine protease predominantly produced and stored in mast cells. It has been studied for its involvement in biological processes such as tissue remodeling and angiogenesis.15,16 According to published literature, mast cells expressing Tryptase have been observed in a variety of human tissues, including those from hematologic […]
CytoFISH products are now manufactured and sold by Empire Genomics, a Biocare Medical company. CytoFISH Multiplex probe is a cocktail of 4 individually fluorescently labeled probes: Copy Control 10 (green), Copy Control 7 (orange), Copy Control 3 (aqua), and 5p15.2 (red). Amplification at the 5p15.2 locus is strongly linked to high-grade, advanced-stage bladder tumors and […]
The CDKN2A gene, also known as the p16 gene has been implicated in numerous cancers (1). The CDKN2A (p16) gene encodes a cyclin dependent kinase inhibitor protein and functions as a cell cycle regulator (1). Gene aberrations involving the CDKN2A gene such as gene deletion and mutation are commonly identified in various cancers (1,2). Homozygous […]
NKX is a prostate-specific tumor suppressor gene and loss of a single allele may predispose to prostate carcinogenesis (1). Studies have shown that the onset of MYC overexpression and the subsequent development of prostatic intraepithelial neoplasia coincide with this reduction in NKX (2). Over-expression of MYC has been reported as an early oncogenic event driving […]
The PTEN del-TECT (4 Color) FISH probe greatly increases the reliability of deletion detection, significantly decreasing the number of falsepositive events2 caused by cell truncation, an artifact of FFPE tissue processing. The PTEN Test probe is labeled in Orange and detects deletions of the PTEN gene. Probe A (WAPAL/BMPR1A) is located centromeric to the test […]
TMPRSS2-ERG rearrangement occurs in approximately 50% of prostate cancers and is associated with an aggressive phenotype (1,2). Both the TMPRSS2 and ERG genes resides on chromosome 21, and gene rearrangements involving the TMPRSS2 and ERG genes lead to the formation of a TMPRSS2-ERG gene fusion product (1,2). ERG is the most commonly overexpressed proto-oncogene in […]
![Tonsil stained with HLA-DR [TAL 1B5] antibody](https://biocare.net/wp-content/uploads/3273.jpg)
HLA-DR (Human Leukocyte Antigen – DR isotype) is a major histocompatibility complex (MHC) class II antigen presentation molecule, critical for the activation of lymphocytes and the coordinating of adaptive immune responses. HLA DR antigen is required for tumor-associated antigen recognition by CD4+ T cells. It is normally expressed on antigen-presenting cells including monocytes, macrophages, dendritic […]
![Tonsil stained with CD247 [BL-336-1B2] antibody](https://biocare.net/wp-content/uploads/3268.jpg)
CD247 is a 16-kDa T-cell surface glycoprotein, also known as CD3 zeta-chain or T-cell antigen receptor (TCR)-Z, which constitutes part of the TCR complex. CD247 is a crucial molecule in the structure, expression, and function of TCR and natural killer (NK) cell-activating receptors. When CD247 is downregulated, T-cell responsiveness and proliferative capacity will be altered […]
STAG1 is a component of cohesin, a ring-shaped protein complex involved in sister chromatid cohesion (SCC) that also plays important roles in the maintenance of chromatin structure, gene expression, and DNA repair. Cohesin consists of a core trimer and one of two mutually exclusive variant STAG subunits, STAG1 and STAG2. STAG1 is thought to primarily […]
![Appendix stained with IFNG [IFNG/3996R] antibody](https://biocare.net/wp-content/uploads/3266.jpg)
Interferon-gamma (IFNG) is a cytokine secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells, natural killer cells, B cells, and antigen-presenting cells. IFNG expression is induced by mitogens and cytokines (1). The downstream target genes of IFNG signaling pathway regulate several biological functions, including cell […]
