Biocare Medical has been busy ensuring you supply the highest quality reagents for your laboratory on every automated platform. Have you seen the latest releases from us, such as CD137, PSAP and LMO2? We have increased our menu of antibodies for the Leica Bond* with our Q Series reagents and the Roche BenchMark Ultra with […]
![Prostate stained with PSAP [rACCP/1338] antibody](https://biocare.net/wp-content/uploads/3263.jpg)
Prostate-specific acid phosphatase (PSAP) is an enzyme produced in prostate epithelial cells. PSAP expression levels proportionally increase with prostate cancer progression.15 PSAP IHC staining is often used in conjunction with prostate specific antigen (PSA) staining to help distinguish poorly differentiated carcinomas. For instance, PSAP is commonly used to help differentiate prostate adenocarcinoma and urothelial carcinoma […]
The prostein gene encodes a 553-amino acid type IIIa plasma membrane protein with a cleavable signal peptide and 11 transmembrane-spanning regions (1). IHC analysis has demonstrated that the Prostein antibody (also known as P501S) was expressed in the normal prostate tissue and the vast majority of malignant prostatic tissues, regardless of grade and metastatic status […]
![Pancreatic neuroendocrine tumor stained with PGP9.5 [UCHL1/4556R] antibody.](https://biocare.net/wp-content/uploads/3305.jpg)
Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts.15 The protein is highly conserved and localized in neurons and neuroendocrine cells, forming an estimated 5-10% of cytoplasmic protein.16 The detection of fine nerves in peripheral tissues using PGP 9.5 antibodies is […]
Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes and has been implicated in embryogenesis, hematopoiesis, and neuronal and terminal epithelial differentiation.15 TLE1 is involved in the Wnt/β-catenin signaling pathway, which is important in synovial sarcomas, and in […]
Probe Enhancer (RNA) is an ancillary reagent that is used as a diluent for RNA targeting probes in an ISH procedure. Probe Enhancer (RNA) facilitates spreading of probes and reduces drying of RNA during hybridization reactions. Effective hybridization may facilitate enhanced staining and reduce artifacts.
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![Spleen stained with HLA-B [BC43] antibody](https://biocare.net/wp-content/uploads/3289.jpg)
HLA-B is a highly polymorphic protein encoding gene for the major histocompatibility class I (MHC-I) complex.15 MHC class I molecules are expressed on the cell surface, binding and presenting antigenic peptides to CD8+ T lymphocytes to mediate immune responses against intracellular pathogens and cancers.16 Want to Learn More About HLA-B [BC43] Antibody? Download Our Complimentary […]
