Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
Lung cancers are the third most diagnosed cancer in the United States, with about 13.5% of new cancer cases classified as lung, contributing 27.2% of cancer deaths yearly. As of 2011, there were approximately 402,000 people living with lung cancer in the United States. Those diagnosed with lung cancer have a 5 year survival rates […]
Research has shown that deletions of PTEN occur at a very high frequency in prostate cancer (1). Other studies have demonstrated an association between decreased PTEN protein expression and a higher Gleason grade and advanced tumor stage (2). In a study by Yoshimoto, it was demonstrated that the presence of PTEN genomic losses are frequent […]
![Liver cancer stained with CD47 [EPR21794] antibody](https://biocare.net/wp-content/uploads/3284.jpg)
CD47 has been shown to have a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.15 In the brain, it appears to play an important role in memory formation and synaptic plasticity in the hippocampus.16 CD47 is a receptor for SIRPA, binding to […]
TRBC1 is a rabbit polyclonal antibody that is intended for laboratory use after the initial diagnosis of tumor has been made by conventional histopathology using nonimmunologic histochemical stains, in the qualitative identification of TRBC1 protein by immunohistochemistry (IHC) in formalin-fixed paraffinembedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be […]
![Prostate stained with PSAP [rACCP/1338] antibody](https://biocare.net/wp-content/uploads/3263.jpg)
Prostate-specific acid phosphatase (PSAP) is an enzyme produced in prostate epithelial cells. PSAP expression levels proportionally increase with prostate cancer progression.15 PSAP IHC staining is often used in conjunction with prostate specific antigen (PSA) staining to help distinguish poorly differentiated carcinomas. For instance, PSAP is commonly used to help differentiate prostate adenocarcinoma and urothelial carcinoma […]
![Tonsil stained with TIM3 [BLR033F] antibody](https://biocare.net/wp-content/uploads/3258.jpg)
TIM3 or T-cell Immunoglobulin domain and Mucin domain 3 can be expressed on both tumor and immune cells including T helper type 1 (Th1) cells, Th17 and CD8+ T cells, tumor infiltrating lymphocytes (TILs), regulatory T cells and innate immune cells (1). TIM3 acts as a negative regulator of Th1/Tc1 (T cytotoxic type 1) function […]
The OX40 receptor, also known as CD134, is a tumor necrosis superfamily receptor (TNSFR4) that is recognized as a costimulatory receptor for T cells. OX40 is predominantly expressed on activated CD4 T cells. OX40 has been shown to be essential for the regulation, differentiation, and survival of conventional CD4 and CD8 T cells.1 Multiple studies […]
![Tonsil stained with TIGIT [BC41] antibody](https://biocare.net/wp-content/uploads/3254.jpg)
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory domain (TIGIT) is a transmembrane glycoprotein receptor expressed in regulatory and memory T cells, natural killer (NK), and activated T cells (1). As a member of the immunoglobulin superfamily, TIGIT has coinhibitory effects on T-cell dependent immune responses, playing an important role in transplantation tolerance and tumor immune surveillance […]
