High molecular weight cytokeratins are expressed in a variety of normal and neoplastic epithelial tissues.15 p63, a homolog of the tumor suppressor p53, has been identified in proliferating basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium and prostate.16 αMethylacyl coenzyme A racemase (AMACR), also known as P504S, is […]
α-Methylacyl coenzyme A racemase (AMACR), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β oxidation of branched chain fatty acids (1). AMACR was initially identified from a cDNA library as a gene that is overexpressed in human prostate cancer; with little or no expression […]
High molecular weight cytokeratins are expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate, CK HMW [34βE12] has been shown to be a useful marker of basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; whereas invasive prostatic adenocarcinoma typically lacks a basal cell […]
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
Studies have shown that in normal epithelia, HMW Cytokeratins (CK5 and CK14) stain stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi.15 p63 is detected in prostate basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus, p63 is useful as a differential marker […]
![Prostate stained with CK HMW [34βE12]](https://biocare.net/wp-content/uploads/3056.jpg)
CK HMW [34BE12], 3X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin HMW [34βE12], catalog numbers CM127, PM127, IPI127, OAI127 as a substitute. 34βE12 recognizes cytokeratins (CK) 1, 5, 10 and 14 (1). In normal prostate, 34βE12 typically […]
AMACR (RM), 3X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer AMACR (RM) or AMACR (RM), 2X, catalog numbers APA3024, OAA3024 or APA3016 as a substitute. α-Methylacyl coenzyme A racemase (AMACR Antibody), also known as P504S, is a peroxisomal […]
α-Methylacyl coenzyme A racemase (AMACR Antibody), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry, AMACR Antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found […]
α-Methylacyl coenzyme A racemase (AMACR antibody), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry (IHC), AMACR antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been […]
