![Kaposi sarcoma stained with HHV-8 [13B10] antibody](https://biocare.net/wp-content/uploads/3290.jpg)
Human herpesvirus 8 (HHV-8) also known as Kaposi sarcoma-associated herpesvirus (KSHV), encodes a latent nuclear antigen which is the product of the viral gene ORF73.1 The protein is expressed predominantly during viral latency and appears to play a role in viral integration into the host genome.1 HHV-8 is associated with Kaposi’s sarcoma, primary effusion lymphoma, […]
Immunoglobulin lambda light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Lambda Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human lambda light chain mRNA.
Immunoglobulin kappa light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Kappa Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human kappa light chain mRNA.
![Tonsil stained with VISTA [BLR035F] antibody](https://biocare.net/wp-content/uploads/3271-1.jpg)
V-domain Ig-containing suppressor of T cell activation (VISTA), also known as PD-1H, is a member of the immunoglobulin (Ig) superfamily, whose extracellular domain bears homology to the B7 family ligand, particularly PDL1. VISTA is predominantly expressed on granulocytic, myeloid cells and T cells.15 VISTA expresses on T cells as a part of an inhibitory immune […]
The MET (7q31) Orange + Copy Control 7 Green FISH probe is design to detect the MET gene region located on 7q31. MET (7q31) is a protooncogene that encodes a transmembrane tyrosine kinase receptor, and regulates cellular pathways responsible for cell proliferation1. Aberrant activation of MET (7q31) signaling occurs in a subset of cancers such […]
![Tonsil stained with HLA-DR [TAL 1B5] antibody](https://biocare.net/wp-content/uploads/3273.jpg)
HLA-DR (Human Leukocyte Antigen – DR isotype) is a major histocompatibility complex (MHC) class II antigen presentation molecule, critical for the activation of lymphocytes and the coordinating of adaptive immune responses. HLA DR antigen is required for tumor-associated antigen recognition by CD4+ T cells. It is normally expressed on antigen-presenting cells including monocytes, macrophages, dendritic […]
![Tonsil stained with CD247 [BL-336-1B2] antibody](https://biocare.net/wp-content/uploads/3268.jpg)
CD247 is a 16-kDa T-cell surface glycoprotein, also known as CD3 zeta-chain or T-cell antigen receptor (TCR)-Z, which constitutes part of the TCR complex. CD247 is a crucial molecule in the structure, expression, and function of TCR and natural killer (NK) cell-activating receptors. When CD247 is downregulated, T-cell responsiveness and proliferative capacity will be altered […]
STAG1 is a component of cohesin, a ring-shaped protein complex involved in sister chromatid cohesion (SCC) that also plays important roles in the maintenance of chromatin structure, gene expression, and DNA repair. Cohesin consists of a core trimer and one of two mutually exclusive variant STAG subunits, STAG1 and STAG2. STAG1 is thought to primarily […]
![Brain stained with Pan TRK [RM423] antibody](https://biocare.net/wp-content/uploads/3267.jpg)
The Biocare Pan TRK [RM423] rabbit monoclonal antibody targets the neurotrophic tyrosine receptor kinase (NTRK) proto-oncogenes. The NTRK proto-oncogenes NTRK1, NTRK2, and NTRK3 (that encode TRK A, TRK B, and TRK C proteins, respectively) may form gene fusions through their kinase domains, driving tumor development.15 TRK A is activated by nerve growth factor (NGF), TRK […]
![Colon Ca stained with BRAF V600E [VE1] antibody](https://biocare.net/wp-content/uploads/3248.jpg)
BRAF, a serine-threonine protein kinase, is a member of the RAF kinase family and plays an important role in the RAS-RAF-MAPK signaling pathway, which regulates cell survival, proliferation and differentiation.(1) Mutations in BRAF results in pathway alteration and sustained kinase activity which lead to carcinogenesis. The bulk of these mutations occur when an amino acid […]
