HPV Probes Download HPV 6 Probe Download HPV 11 Probe Download HPV 16 Probe Download HPV 18 Probe Download HPV 31 Probe Download HPV 51 Probe Download CISH DNA 1 Temp1 Download CISH DNA 2 Temp1 Download ONCORE Pro Warp Red Chromogen Kit Download ONCORE Pro Hematoxylin Download Molecular Probe / Templates Download ALK […]
![Tonsil stained with TIGIT [BC41] antibody](https://biocare.net/wp-content/uploads/3254.jpg)
28
Jan
Jan
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory domain (TIGIT) is a transmembrane glycoprotein receptor expressed in regulatory and memory T cells, natural killer (NK), and activated T cells (1). As a member of the immunoglobulin superfamily, TIGIT has coinhibitory effects on T-cell dependent immune responses, playing an important role in transplantation tolerance and tumor immune surveillance […]
26
Jun
Jun
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory domain (TIGIT) is a transmembrane glycoprotein receptor expressed in regulatory and memory T cells, natural killer (NK), and activated T cells (1). As a member of the immunoglobulin superfamily, TIGIT has coinhibitory effects on T-cell dependent immune responses, playing an important role in transplantation tolerance and tumor immune surveillance […]
22
Apr
Apr
CD8 [C8/1779R] is a rabbit monoclonal antibody that is intended for laboratory use in the qualitative identification of CD8a protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of […]
07
Jan
Jan
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. (1-3). […]
03
Jan
Jan
LAG-3 (Lymphocyte Activation Gene 3) is a surface receptor expressed on activated T cells, an exhaustion marker with immunosuppressive activity (1). Major histocompatibility complex class II (MHC-II) is a ligand for LAG-3; additional ligands (e.g., LSECtin and galectin-3) have also been identified (1,2). Regulatory T cells (Tregs) expressing LAG-3 have enhanced suppressive activity, whereas cytotoxic […]
03
Jan
Jan
GITR (Glucocorticoid-induced TNF-R-related protein, TNFRSF18, CD357) is a co-stimulatory cell surface receptor constitutively expressed at high levels on T regulatory cells (Tregs), at intermediate levels on NK cells, and at low levels on naïve and memory T cells, and macrophage and dendritic cells (DCs) (1-2). Of all immune subsets studied, activated Tregs exhibit the highest […]
19
Dec
Dec
Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
21
Mar
Mar
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 exhibits cell surface and intracellular constitutive expression on memory T-cells and at a low level by T-regulatory cells (Tregs; 2-4% of circulating CD4+ T cells) (1,2). CTLA-4 primarily inactivates T-cell activity by […]
26
Oct
Oct
Retineic-acid-receptor-related orphan nuclear receptor gamma (RORγt) is considered to be one of the master regulators in the development of T helper 17 cells (Th17 cells), which have an essential role in the development of many autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and psoriasis (1). RORγT was initially identified as a transcription […]
