HPV Probes Download HPV 6 Probe Download HPV 11 Probe Download HPV 16 Probe Download HPV 18 Probe Download HPV 31 Probe Download HPV 51 Probe Download CISH DNA 1 Temp1 Download CISH DNA 2 Temp1 Download ONCORE Pro Warp Red Chromogen Kit Download ONCORE Pro Hematoxylin Download Molecular Probe / Templates Download ALK […]
![Breast carcinoma stained with PCNA [PC10] antibody](https://biocare.net/wp-content/uploads/3255.jpg)
21
Jul
Jul
Proliferating cell nuclear antigen (PCNA) is necessary for DNA synthesis and is an accessory protein for DNA polymerase alpha, which is elevated during the G1/S phase of the cell cycle. PCNA forms a ring around a portion of DNA, serving to anchor the various DNA replication and repair proteins and to regulate proliferation throughout the […]
The skin is the largest human body organ. It is comprised of many different layers, each with its own unique function and susceptibility to abnormalities. Melanoma is a deadly skin disease known for its aggressive clinical behavior and high tendency to metastasize.1 Most melanomas can be accurately diagnosed by examining histological features, including asymmetry, lack […]
The success of an immunohistochemical (IHC) process can be linked to pre-analytical steps of the histological process, as these steps can significantly and adversely affect accurate detection of targets. Preserving the integrity of tissue collected for pathological examination is of utmost importance and is achieved through a process called fixation. While chemical fixation denatures and […]
![Astrocytoma stained with IDH1 R132H [IHC132] antibody](https://biocare.net/wp-content/uploads/3253.jpg)
06
May
May
Isocitrate dehydrogenase 1 (IDH1) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH.15 However, abnormal IDH1 caused by somatic missense mutations may occur when substitution from arginine to histidine at codon 132 (IDH1 R132H) inhibits the wild-type IDH1 enzymatic activity, leading to production of 2- hydroxyglutarate, a possible oncometabolite. The […]
06
May
May
ATRX plays a role in chromatin regulation and maintenance of telomeres. It regulates incorporation of histone H3.3 into telomeric chromatin (1). ATRX is also a major component of various essential cellular pathways such as DNA replication and repair, chromatin higher-order structure regulation, gene transcriptional regulation, etc. (2) ATRX loss was observed in grades II/III astrocytomas, […]
Claudins and Cancer: Promising Proteins for Detection and Diagnosis Claudin family proteins are transmembrane proteins that serve as major cell adhesion molecules of tight junctions. “Tight junctions restrict the flow of ions and aqueous molecules between cells, and their permeability is determined by the profile of claudin expression and arrangement of claudins […]
20
Jan
Jan
p16 INK4a is a tumor suppressor protein involved in the pathogenesis of a variety of malignancies and is a 16.5 kDa protein expressed in the nucleoplasm of proliferating cells, functioning as an inhibitor of CDK4. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. p16 INK4a […]
Increased Staining Consistency and Clarity on the ONCORE Pro X for Multiplex Staining Download pdf Clone Wars – CDX2 – Comparative Analysis Download pdf Understanding FISH vs NGS Capabilities Download pdf Let’s Get Clinical: Understanding Mismatch Repair and Microsatellite Instability Download pdf FISH and Cytogenetic Analysis: Probing for CLL and MDS Download pdf Probing Questions: […]
What Tissues Are You Working With?
