Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![Spleen stained with HLA-B [BC43] antibody](https://biocare.net/wp-content/uploads/3289.jpg)
HLA-B is a highly polymorphic protein encoding gene for the major histocompatibility class I (MHC-I) complex.15 MHC class I molecules are expressed on the cell surface, binding and presenting antigenic peptides to CD8+ T lymphocytes to mediate immune responses against intracellular pathogens and cancers.16 Want to Learn More About HLA-B [BC43] Antibody? Download Our Complimentary […]
ONCORE Pro Hematoxylin is water-based and is specially formulated for counterstaining on Biocare’s ONCORE Pro Automated Stainer. ONCORE Pro Hematoxylin stains nuclei sky-blue and provides high contrast staining for chromogenic staining procedures.
![Kaposi sarcoma stained with HHV-8 [13B10] antibody](https://biocare.net/wp-content/uploads/3290.jpg)
Human herpesvirus 8 (HHV-8) also known as Kaposi sarcoma-associated herpesvirus (KSHV), encodes a latent nuclear antigen which is the product of the viral gene ORF73.1 The protein is expressed predominantly during viral latency and appears to play a role in viral integration into the host genome.1 HHV-8 is associated with Kaposi’s sarcoma, primary effusion lymphoma, […]
p27 KIP1 is a member of the Cyclin Inhibitory Protein/Kinase Inhibitory Protein (CIP/KIP) family of cyclin-dependent kinase (Cdk) inhibitors.15 It plays roles in all phases of the cell division cycle. Thus, important cellular functions as the cell division cycle, respiration, RNA processing, translation, and cell adhesion, are under p27 KIP1 regulation.15 Reduced levels of p27 […]
The Mouse Amp AP Detection is intended for use in automated Immunohistochemistry (IHC) staining protocols using an alkaline phosphatase (AP) polymer one-step application method. This micro-polymer detection kit is designed for the detection of mouse IgG and IgM primary antibodies bound to target antigens in the formalin-fixed, paraffin-embedded (FFPE) tissues during the IHC staining process. […]
Fast Red is a well-established chromogen used in IHC staining protocols that in the presence of an alkaline phosphatase (AP) enzyme, produces a bright fuchsin-red precipitate that is insoluble in organic solvents and can be coverslipped with a permanent mounting media. ONCORE Pro Warp Red Chromogen Kit contains two solutions: Warp Red Chromogen and the […]
The Rabbit Amp AP Detection is designed using a one-step method for detecting Rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the one-step method a secondary antibody directly linked to the micropolymer is applied. Rabbit Amp AP Detection is provided ready-to-use and is intended to […]
![Tonsil stained with CD20 [BC30] antibody](https://biocare.net/wp-content/uploads/3287.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B-cell lymphoma cells making […]
