Immunoglobulin lambda light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Lambda Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human lambda light chain mRNA.
The Epstein – Barr virus is a member of the gamma-herpes viruses (HHV-4). Epstein-Barr Encoded (EBER) Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind EBER-1 and EBER-2 mRNA sequences that may be expressed in latently infected cells.1
Immunoglobulin kappa light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Kappa Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human kappa light chain mRNA.
![Tonsil stained with CD20 [BC30] antibody](https://biocare.net/wp-content/uploads/3287.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B-cell lymphoma cells making […]
![Tonsil stained with Hairy Cell Leukemia [DBA.44] antibody](https://biocare.net/wp-content/uploads/3279.jpg)
Hairy Cell Leukemia is a rare hematological malignancy in which B-cell lymphocytes are produced in excessive quantities. Hairy Cell Leukemia is characterized by small lymphocytes bearing fine hair-like cytoplasmic projections with infiltration of reticuloendothelial organs such as lymphoid organs and bone marrow.15,16 This mouse monoclonal antibody, also referred to as DBA.44, may be used in […]
Carbonic anhydrase 9 (CA-9) is a transmembrane zinc metalloenzyme which has a function in cell-cell adhesion and plays an important role in tumor growth and survival under normoxia and hypoxia.15 Upregulation of CA-9 in tumors is an effective adaptive response to hypoxia and increases the tumor cell survival.16 CA-9 expression is mostly restricted to the […]
The OCT 3/4 transcription factor, a member of the POU family, is expressed in totipotent embryonic stem cells (ES) and germ cells.15 OCT 3/4 has a unique role in development and in the determination of pluripotency.15 OCT 3/4 immunohistochemistry staining has been shown to be a useful marker for a wide variety of gonadal and […]
PBX1 (1q23.3) Orange FISH Probe is intended to hybridize to the 1q23.3 probe region on chromosome 1. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
Antigen Retrieval 3 (AR3) is capable of partially breaking the covalent bonds of formalin-fixed tissue, as part of an ISH staining procedure on the ONCORE Pro Automated Slide Stainer. Pretreatment of FFPE tissues with Antigen Retrieval 3 (AR3) can increase staining intensity. Probe Enhancer (RNA) is an ancillary hybridization reagent that promotes spreading and reduces […]
The ONCORE Pro-Tect Detection Kit is designed using a two-step or threestep method for detecting mouse and/or rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the two-step method (rabbit), the universal linker is applied, then an additional enzyme-linked polymer labeled reagent is sequentially applied. In […]
