Pan Cytokeratin antibody Plus is a combination of [AE1/AE3] and Cytokeratin (CK) 8/18 [5D3] and can be used to detect most human epithelia. [AE1/AE3] recognizes acidic and basic subfamilies of cytokeratins, with molecular weights ranging from 40 to 67 kDa. CK8/18 [5D3] recognizes Cytokeratin 8 and 18 intermediate filament proteins. In normal tissues, [5D3] recognizes […]
Studies have shown that in normal epithelia, HMW Cytokeratins (CK5 and CK14) stain stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi.15 p63 is detected in prostate basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus, p63 is useful as a differential marker […]
Cytokeratin 5/14 Cocktail, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5/14 Cocktail, catalog numbers ACI3025 & API3025 as a substitute. CK5 [XM26] has been shown to have positive reactivity for CK5 protein and lack of reactivity […]
Cytokeratin 19 antibody reacts with the rod domain of human keratin 19, a 40kDa polypeptide. The antibody reacts with MCF-7 cells and has been shown to label trichoblastoma, thyroid tumors, oral cancer, and epithelial odontogenic tumors. CK19 is not expressed in most hepatocytes, therefore cytokeratin 19 is useful in the identification of liver metastasis and […]
Cytokeratin 18 (CK18) is a 45 kDa acidic intermediate filament protein. It is normally coexpressed with cytokeratin 8 and is found in most simple ductal and glandular epithelia.15 The antibody reacts with a wide variety of neoplastic tissues such as gastrointestinal tract, lung, and breast tumors;16-18 whereas tumor cells of nonepithelial origin such as glioma, […]
IHC markers CK5, CK14, p63, CK7 and CK18 complement morphological evaluation of breast lesions, due to the differential expression of the luminal (CK7/18) vs. basal and myoepithelial markers (CK5/14, p63). Usual ductal hyperplasia is associated with positive basal cells markers, intermixed with positive luminal cells. Most atypical ductal hyperplasia and low grade ductal carcinoma in […]
![Colon cancer stained with SATB2 [CL0323] antibody](https://biocare.net/wp-content/uploads/3259-SATB2.jpg)
SATB2 (special AT-rich sequence binding 2) is a human DNA-binding protein involved in transcriptional regulation and chromatin remodeling.15,16 SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract including appendix, colon and rectum. SATB2 protein expression was also found in non–germinal center lymphoid cells, and the ductal epithelium […]
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SATB2 (special AT-rich sequence binding 2) is a 733-amino acid human DNA-binding protein involved in transcriptional regulation and chromatin remodeling (1,2). SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract (including appendix, colon, and rectum), as well as specific neurons (in the cerebral cortex and hippocampus), non–germinal […]
