The Cytokeratin 5 (CK5) (R) [EP42] antibody is a rabbit monoclonal antibody raised for the detection of cytokeratin 5, a type II intermediate filament protein. CK5 is expressed in the active basal layers of most stratified squamous epithelia.15 CK5 has been identified as a specific immunohistochemical marker for lung squamous cell carcinoma (SqCC), with minimal […]
Cytokeratin 19 antibody reacts with the rod domain of human keratin 19, a 40kDa polypeptide. The antibody reacts with MCF-7 cells and has been shown to label trichoblastoma, thyroid tumors, oral cancer, and epithelial odontogenic tumors. CK19 is not expressed in most hepatocytes, therefore cytokeratin 19 is useful in the identification of liver metastasis and […]
Cytokeratin 18 (CK18) is a 45 kDa acidic intermediate filament protein. It is normally coexpressed with cytokeratin 8 and is found in most simple ductal and glandular epithelia.15 The antibody reacts with a wide variety of neoplastic tissues such as gastrointestinal tract, lung, and breast tumors;16-18 whereas tumor cells of nonepithelial origin such as glioma, […]
CD31 recognizes a 100kDA glycoprotein in endothelial cells and 130kD in platelets. It reacts weakly with mantle zone B-cells, peripheral T-cells, and neutrophils.15 CD31 can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow.15-17 CD31 can […]
Calretinin is a calcium binding protein that is related to calmodulin and calbindin-D28k and is found mainly in neuronal tissue. It is present in subsets of neurons throughout the brain and spinal cord, including sensory ganglia.15-19
Arginase-1 (ARG-1) is a key enzyme of the urea cycle found in liver that catalyzes the conversion of L-arginine into L-ornithine and urea. ARG-1 is a highly specific and sensitive marker of benign and hepatocellular carcinoma (HCC) which is now a key target for the differential diagnosis of HCC from metastatic tumors to the liver.15-17 […]
AMACR (RM), 3X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer AMACR (RM) or AMACR (RM), 2X, catalog numbers APA3024, OAA3024 or APA3016 as a substitute. α-Methylacyl coenzyme A racemase (AMACR Antibody), also known as P504S, is a peroxisomal […]
