The p53 tumor suppressor protein is encoded by the TP53 gene located on chromosome 17p13. Under normal conditions the TP53 gene functions as a safeguard in maintaining cellular homeostasis (1). Furthermore, the TP53 gene regulates suppressive mechanisms that mediate cell cycle arrest, senescence and apoptosis (1). Chromosomal abnormalities involving the TP53 gene are associated with […]
TP53 is the gene which encodes for the p53 tumor suppressor protein. TP53 is activated in many forms of cellular stress including carcinogensis and exerts multiple anti-proliferatiuve functions1. TP53 mutations are one of the most common findings in many human cancers and has been proposed as an effective measure of prognosis2. Typically the prescence of […]
The p53 tumor suppressor protein is encoded by the TP53 gene located on chromosome 17p13. Under normal conditions the TP53 gene functions as a safeguard in maintaining cellular homeostasis1. Furthermore, the TP53 gene regulates suppressive mechanisms that mediate cell cycle arrest, senescence and apoptosis1. Chromosomal abnormalities involving the TP53 gene are associated with several hematological […]
p53 (RM), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p53, catalog numbers CME298, PME298, IP298 as a substitute. The tumor suppressor p53 plays a key role in regulating urothelial growth and genomic stability. Increased expression of p53 […]
Uro-2 (CK20 + p53) is a primary antibody cocktail for the multiplex IHC identification of CK20 and p53 proteins in bladder. Studies have shown that in normal urothelium, the superficial umbrella cell layer shows reactivity for CK20 only; whereas, p53 nuclear staining is absent to focal. For urothelium with reactive atypia, particularly in cases with […]
p53 Tumor Suppressor Protein (M) [DO-7] recognizes a 53 kDa phosphoprotein identified as the p53 suppressor gene product. It reacts with both mutant and wild type p53. Its epitope maps within the N-terminus (aa 37-45) of p53. p53 acts both as a tumor-suppressor and transcription factor. Activation by DNA damage or other stress signals triggers […]
p53 acts both as a tumor-suppressor and transcription factor. Activation by DNA damage or other stress signals triggers cell-cycle arrest, apoptosis and DNA repair. The nuclear p53 gene is located on chromosome 17p, a frequent site of allele loss in many tumors (60%) including breast, colon and lung. This antibody recognizes both wild-type and mutant […]
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