Uroplakin II (UPII) and Uroplakin III (UPIII) are 15 kDa and 47 kDa proteins, respectively, that are key components of urothelial plaques, which enhance the permeability barrier of the urothelium.15 UPII and UPIII may be found in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. UPII and UPIII have also been […]
Uroplakin III is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. Uroplakin III [BC17] demonstrated a higher sensitivity compared with [AU1] on urothelial transitional cell carcinomas, in in-house studies. [BC17] staining was negative in all normal and neoplastic tissues except for bladder; hence it is highly specific to uroepithelial […]
Bladder cancer is the seventh most commonly occurring cancer in the United States with 73,469 new cases reported in 2016 and is associated with high recurrence & progression rates. Bladder cancer is the seventh most commonly occurring cancer in the United States with 73,469 new cases reported in 2016 and is associated with high recurrence […]
Distinguishing between invasive urothelial carcinoma (UC) from other genitourinary malignancies, such as prostatic and renal carcinomas, can be difficult. Several new markers such as GATA binding protein 3 (GATA-3), S100P, and uroplakin III have been developed for this differentiation (1-7). More recently uroplakin II has been introduced (1-7). GATA-3 is a transcription factor and belongs […]
Uroplakin II is a 15 kDa protein component of urothelial plaques, which enhance the permeability barrier of the urothelium. 15 Uroplakin II [BC21] is a highly specific antibody that may be useful in identifying tumors of urothelial origin.
Topoisomerase II alpha (Topo IIa) plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor […]
This is a monoclonal antibody to the A-subunit of human coagulation Factor XIII. Studies have shown it recognizes human Factor XIII Achain in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a betaglobulin found in plasma and is composed of two subunits. […]
Concord, CA, May 14, 2013 – Biocare Medical is proud to announce the availability of a new Uroplakin II mouse monoclonal antibody (IVD). Studies have shown UP II mRNA to be expressed in both bladder cancer tissues and peripheral blood of patients with primary and metastatic urothelial carcinoma. Urothelial carcinoma (UC) of the bladder typically […]
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
