![Breast cancer stained with Tumor Associated Glycoprotein antibody [B72.3]](https://biocare.net/wp-content/uploads/wrt1.jpg)
The Tumor Associated Glycoprotein [B72.3] antibody is a mouse monoclonal antibody developed for the detection of a high molecular weight (>1,000 kDa) oncofetal glycoprotein known as TAG-72. TAG-72 exhibits properties consistent with a mucin-like glycoprotein and is associated with various human adenocarcinomas.16 TAG-72 expression has been observed in the majority of adenocarcinomas, including those originating […]
p53 Tumor Suppressor Protein (M) [DO-7] recognizes a 53 kDa phosphoprotein identified as the p53 suppressor gene product. It reacts with both mutant and wild type p53. Its epitope maps within the N-terminus (aa 37-45) of p53. p53 acts both as a tumor-suppressor and transcription factor. Activation by DNA damage or other stress signals triggers […]
![Diffuse Large B-Cell Lymphoma (DLBCL) stained with CD20 [BC44] antibody.](https://biocare.net/wp-content/uploads/3316.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B cell lymphoma cells […]
![Pancreatic neuroendocrine tumor stained with PGP9.5 [UCHL1/4556R] antibody.](https://biocare.net/wp-content/uploads/3305.jpg)
Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts.15 The protein is highly conserved and localized in neurons and neuroendocrine cells, forming an estimated 5-10% of cytoplasmic protein.16 The detection of fine nerves in peripheral tissues using PGP 9.5 antibodies is […]
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![Spleen stained with HLA-B [BC43] antibody](https://biocare.net/wp-content/uploads/3289.jpg)
HLA-B is a highly polymorphic protein encoding gene for the major histocompatibility class I (MHC-I) complex.15 MHC class I molecules are expressed on the cell surface, binding and presenting antigenic peptides to CD8+ T lymphocytes to mediate immune responses against intracellular pathogens and cancers.16 Want to Learn More About HLA-B [BC43] Antibody? Download Our Complimentary […]
![Tonsil stained with CD20 [BC30] antibody](https://biocare.net/wp-content/uploads/3287.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B-cell lymphoma cells making […]
Research has shown that deletions of PTEN occur at a very high frequency in prostate cancer (1). Other studies have demonstrated an association between decreased PTEN protein expression and a higher Gleason grade and advanced tumor stage (2). In a study by Yoshimoto, it was demonstrated that the presence of PTEN genomic losses are frequent […]
