![Melanoma Stained with S100 Protein [4C4.9] (M)](https://biocare.net/wp-content/uploads/3237-1.jpg)
S100 recognizes proteins of 21-24 kDa, identified as the A and B subunits of S100 protein. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is expressed in Schwannomas, ependymomas, […]
CDX2 is a homeobox gene that encodes an intestine-specific transcription factor (1). CDX2 has been useful to establish gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can be especially useful in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin (1-7). CDX2 has been shown to be more specific and more sensitive than villin or […]
Melan-A (MART-1) [A103], a melanoma-specific antigen, is a transmembrane protein and a melanocyte differentiation marker recognized by cytotoxic T lymphocytes. Melan-A is expressed in skin, in the majority of melanocytes and in renal angiomyolipomas.15-17
CDH17 (Cadherin 17 or LI-cadherin) is a novel oncogene which is involved in tumor invasion and metastasis and is expressed in intestinal epithelium.15,16 CDH17 is a highly specific marker in colon cancer (99/99, 100%) and is a more sensitive marker than CDX2 (93/99, 94%) and CK20 (91/99, 92%).17 Overexpression of CDH17 (and conversely, underexpression of […]
The expression of Surfactant-apoprotein-A (SP-A) by tumor cells has been shown to be a helpful diagnostic tool for the identification of primary lung carcinomas. Surfactant-apoprotein-A antibody is expressed in pneumocytes II of lung tissue and in a portion of non-small cell lung carcinomas. Immunohistochemically detected SP-A [32E12] in conjunction with thyroid transcription factor-1 (or other […]
The Biocare S100P antibody recognizes placental S100 binding protein, a member of the S100 family of proteins originally identified in the placenta and later associated with cancer.15,17 Members of the S100 protein family function as extracellular and/or intracellular regulators of diverse cellular processes and are implicated in various human pathologies. Functional studies indicate that S100P […]
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 Protein Cocktail antibody stains melanocytes, schwannomas, peripheral neural tissue, astrocytes, benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells […]
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 antibody stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells in the paracortex […]
p53 Tumor Suppressor Protein (M) [DO-7] recognizes a 53 kDa phosphoprotein identified as the p53 suppressor gene product. It reacts with both mutant and wild type p53. Its epitope maps within the N-terminus (aa 37-45) of p53. p53 acts both as a tumor-suppressor and transcription factor. Activation by DNA damage or other stress signals triggers […]
Heat shock proteins (HSPs) are an important part of the cell’s machinery for protein folding and also help to protect cells from stress. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, Heat Shock Protein 70 antibody (HSP70) directly inhibits apoptosis and has been shown to […]
