CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was […]
The mouse monoclonal antibody p40 [BC28] recognizes an epitope unique to the p40 protein and may have applications in cases where p63 has traditionally been used. To date, p63 [4A4] has been a frequently used marker of basal epithelium in normal prostate, with expression not typically observed in prostatic adenocarcinoma. A study has shown p40 […]
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium.15-17
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
p63, 3X (Prostate) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer p63, catalog numbers CM163, PM163, IP163, VP163, OAI163 as a substitute. p63, a homolog of the tumor suppressor p53, has been identified in proliferating basal cells in the […]
The Muscle Specific Actin antibody [HHF35] recognizes muscle specific alpha and gamma actin isomers. It does not react with non-muscle actin. Studies have shown that it recognizes the alpha actin from cardiac, skeletal and smooth muscle sources. It does not react with beta or non-smooth muscle gamma actin isomers. The antibody labels leiomyoma, leiomyosarcoma, angiomyolipoma […]
Leukocyte Common Antigen Antibody recognizes an antigen found on lymphoid cells. It reacts with B cells, T-cell subtypes, monocytes, macrophages, and is weakly expressed with granulocytes. The PD7/26 antibody was included in the 3rd International Workshop. CD45RB reacts with 3 of the 5 glycoproteins in the CD45 family (MW 190, 205 and 220 kDa). It […]
Studies have shown CD45 recognizes an antigen found on lymphoid cells. Most neoplastic B-cells and T-cells stain positively in leukemia and in non Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative.15-17
Hepatocyte Specific Antigen (HSA) is considered specific for normal and neoplastic hepatocytes.15 Expression has been demonstrated consistently in the majority of hepatocellular carcinomas.15,17,18 Studies have shown HSA can be used in a panel with Glypican-3, CEA, CK7, AFP and CD10.16,18
![Breast cancer stained with Epithelial Membrane Antigen (EMA) [E29]](https://biocare.net/wp-content/uploads/3038.jpg)
The Biocare Epithelial Membrane Antigen (EMA) antibody recognizes a heterogeneous family of highly glycosylated transmembrane proteins known as human milk fat globule (HMFG) membrane proteins. Although originally identified in breast tissue, EMA expression is also found in secretory epithelial cells, to a lesser degree in non-secretory epithelium (e.g., squamous epithelium), and rarely in non-epithelial cells.15,18 […]
