![Colon cancer stained with Pan Cytokeratin [AE1/AE3] antibody.](https://biocare.net/wp-content/uploads/011-2.jpg)
AE1/AE3 recognizes the acidic and basic (Type I and II) subfamilies of cytokeratins. The cocktail of these two antibodies can be used to detect most human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48, 46, 45, and 40 kDa. The basic cytokeratins have molecular weights of 65-67, 64, 59, […]
![Brain stained with Pan TRK [RM423] antibody](https://biocare.net/wp-content/uploads/3267.jpg)
The Biocare Pan TRK [RM423] rabbit monoclonal antibody targets the neurotrophic tyrosine receptor kinase (NTRK) proto-oncogenes. The NTRK proto-oncogenes NTRK1, NTRK2, and NTRK3 (that encode TRK A, TRK B, and TRK C proteins, respectively) may form gene fusions through their kinase domains, driving tumor development.15 TRK A is activated by nerve growth factor (NGF), TRK […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells).1 MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions.1,2 Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas.3 This MART-1 cocktail does not stain steroid tumors. Tyrosinase […]
Pan Melanoma Antibody +S100 (Tyrosinase) is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. MART-1 (M2-7C10 + M2-9E3) recognizes a protein of […]
Pan Melanoma Antibody + Ki-67 serves as a tool to identify the proliferation rate of melanocytic lesions in cases in which melanocytes are sparse; there are dense lymphocytic infiltrates; and melanocytes are admixed with fibroblasts. In general, a higher proliferative fraction is seen in melanoma than in melanocytic nevi. There are many types of nevi, […]
![Colon cancer stained with Pan Cytokeratin [Lu-5] antibody](https://biocare.net/wp-content/uploads/lw.jpg)
Pan Cytokeratin [Lu-5] antibody is has been demonstrated as a useful marker for the differentiation of epithelial and mesothelial cells from mesenchymal cells in normal and tumor tissues. It has been shown to serve as a first-order pan cytokeratin antibody for both acidic (type I) and basic (type II) cytokeratin subfamilies of all vertebrates tested […]
Pan Cytokeratin antibody Plus is a combination of [AE1/AE3] and Cytokeratin (CK) 8/18 [5D3] and can be used to detect most human epithelia. [AE1/AE3] recognizes acidic and basic subfamilies of cytokeratins, with molecular weights ranging from 40 to 67 kDa. CK8/18 [5D3] recognizes Cytokeratin 8 and 18 intermediate filament proteins. In normal tissues, [5D3] recognizes […]
Tumor protein p63 antibody, also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene. Many studies have shown that p63 is a sensitive (90%) and fairly specific marker for squamous cell carcinoma and may be used in distinguishing poorly differentiated lung squamous cell carcinomas (SqCC) from adenocarcinomas. […]
Cytokeratin 5/14 Cocktail, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5/14 Cocktail, catalog numbers ACI3025 & API3025 as a substitute. CK5 [XM26] has been shown to have positive reactivity for CK5 protein and lack of reactivity […]
CK5 is distributed in many non-keratinizing stratified squamous epithelia such as tongue mucosa, basal epithelia, hair follicles, trachea, as well as basal cells in prostate glands and myoepithelial cells in mammary glands.15-19 CK5 is also expressed in most epithelial and biphasic mesotheliomas. CK5 has also been noted in large cell carcinomas and pulmonary squamous cell […]
